117096-61-4

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 3-benzoyl-7-hydroxy-2-phenyl-
• CAS NO: 117096-61-4
• Molecular Formula: C22H14O4
• Molecular Weight: 342.351
• Mol File: 117096-61-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 3-benzoyl-7-hydroxy-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 3-benzoyl-7-hydroxy-2-phenyl-(117096-61-4)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 3-benzoyl-7-hydroxy-2-phenyl-(117096-61-4)

Safety Data

• Hazardous Substances Data: 117096-61-4(Hazardous Substances Data)

Upstream product

• 708268-55-7 3-benzoyl-7-benzoyloxy-2-phenyl-chromen-4-one 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 93-97-0 benzoic acid anhydride 
• 66832-97-1 2,4-dibenzoyloxyacetophenone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 39103-37-2 7-benzoyloxy-2-phenyl-4H-1-benzopyran-4-one 
• 21785-09-1 7-methoxyflavanone 
• 37884-21-2 7-Methoxy-2-phenyl-chroman-4-one oxime 
• 6665-86-7 7-hydroxyflavone 

Relevant articles and documents

Synthesis and properties of 3-acyl-γ-pyrones, a novel class of flavones and chromones

Using modified Baker-Venkataraman reaction a novel class of 3-acyl flavones and chromones have been synthesised. Reaction mechanism for their formation have been elucidated. The properties of 3-acyl flavonoids indicate them to be precursors for the synthesis of flavones.

New syntheses of 3-aroylflavone derivatives; Knoevenagel condensation and oxidation versus one-pot synthesis

Two syntheses of 3-aroylflavones have been established. In the first synthesis the use of microwave irradiation led to an improvement in the yields of both the Knoevenagel condensation of β-diketones with aldehydes to afford 3-aroylflavanones and of their

Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties

(3-Phenyl-7-flavonoxy)propanolamines have been shown to exhibit antihypertensive activity in spontaneously hypertensive rats. Although they are structurally similar to classical β-adrenergic blocking compounds, their activity is not due to inhibition of β-adrenoceptors. In the present study, a series of simple flavonoxypropanolamines was prepared to further explore the structural requirements for the antihypertensive effect of these compounds. A structure-activity relationship of these derivatives indicates that the position of the oxypropanolamine side chain, the hydroxy group of the side chain, steric bulkiness and length of N substituents, degree of the N-substitution, phenyl group at the 2-position of the chromone nucleus, and substituents of the phenyl group or B ring of the flavone play significant roles in imparting pharmacological effects. In addition, there is a good correlation between the antihypertensive activity and depletion of myocardial norepinephrine. Of these analogues tested, the most effective one was flavodilol (3). Only the 8-substituted analogue 6 was found to be a β-antagonist. Flavodilol was chosen for in-depth pharmacological, toxicological, and clinical evaluation.