39103-37-2

Upstream product

• 5465-06-5 <4-(benzoyloxy)-2-hydroxybenzoyl>benzoylmethane 
• 532-32-1 sodium benzoate 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 93-97-0 benzoic acid anhydride 
• 6665-86-7 7-hydroxyflavone 
• 98-88-4 benzoyl chloride 
• 66832-97-1 2,4-dibenzoyloxyacetophenone 
• 117096-61-4 7-hydroxy-2-phenyl-3-benzoylchromone 

Downstream Products

• 101636-03-7 5-(7-benzoyloxy-2-phenyl-chromen-4-ylidene)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 6665-86-7 7-hydroxyflavone 
• 42345-25-5 7-hydroxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde 
• 63790-45-4 7-methoxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde 

Relevant academic research and scientific papers

Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor

Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series.

Facile synthesis of 9-acetyl/formyl/cyano-substituted pyrano[2,3-f]flavones and chromones using the baylis-hillman reaction

Condensation of 8-formyl-7-hydroxyflavones (2a-f) and 8-formyl-7-hydroxy-2- (2'-furyl)-3-methylchromone (2g) with methyl vinyl ketone (3), acrolein (4), and acrylonitrile (5) in the presence of diazabicyclo[2.2.2]octane (DABCO) under an N2 atmosphere at room temperature using Baylis-Hillman reaction conditions afforded 9-acetyl/formyl/cyano-substituted pyrano2,3-f]flavones (6a-f, 7a-f, 8a-f) and chromones (6g, 7g, 8g).

Facile synthesis of 7-methoxy-2-aryl-3-phenyl/or-H-8-[2-(4,6-dimethyl-3,5- dicarbethoxy-pyridyl)]-4H-1-benzopyran-4-ones

Condensation of 8-formyl-7-methoxy-2-phenyl-4H-1-benzopyran-4-ones (5a-f) with ethyl-3-aminocrotonate (6) in glacial acetic acid under Hantzsch conditions afforded 7-methoxy-2-aryl-3-phenyl/or-H-8-[2-(4,6-dimethyl-3,5-dicarbethoxy- pyridyl)]-4H-1-benzopyran-4-ones (7a-f) in good yields. Copyright Taylor & Francis Group, LLC.

Synthesis and properties of 3-acyl-γ-pyrones, a novel class of flavones and chromones

Using modified Baker-Venkataraman reaction a novel class of 3-acyl flavones and chromones have been synthesised. Reaction mechanism for their formation have been elucidated. The properties of 3-acyl flavonoids indicate them to be precursors for the synthesis of flavones.