1510832-19-5

Basic information

• Product Name: 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1510832-19-5
• Molecular Weight: 432.563
• Mol File: 1510832-19-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester(1510832-19-5)
• EPA Substance Registry System: 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester(1510832-19-5)

Safety Data

• Hazardous Substances Data: 1510832-19-5(Hazardous Substances Data)

Upstream product

• 1510832-11-7 C₃₅H₄₂N₆O₁₂S₂ 
• 68-11-1 mercaptoacetic acid 
• 108-98-5 thiophenol 
• 1510832-15-1 (1S,4S)-5-((2-nitrophenyl)sulfonyl)-2-oxa-5-azabicyclo[2.2.2]octan-3-one 
• 63088-78-8 (2S,5R)-5-hydroxypiperidine-2-carboxylic acid 
• 1510832-12-8 C₁₂H₁₄N₂O₇S 
• 1510832-18-4 tert-butyl 4-((2S,5S)-1-((2-nitrophenyl)sulfonyl)-5-(((2-nitrophenyl)sulfonyl)oxy)piperidine-2-carboxamido)piperidine-1-carboxylate 
• 1416134-47-8 (2S,5R)?5?[(benzyloxy)amino]piperidine?2?carboxylate 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 1171080-44-6 (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid benzyl ester 
• 53100-44-0 L-N-t-butoxycarbonylpyroglutamic acid 
• 1033774-90-1 N-4-nitrobenzene sulfonyl-O-benzylhydroxylamine 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 

Downstream Products

• 1174020-63-3 tert-butyl 4-((1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate 
• 1174018-99-5 (2S,5R)-sulfuric acid mono{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl}ester 

Relevant articles and documents

Preparation method of Rayleigh bactam intermediate

The invention discloses a preparation method of a Rayleigh bactam intermediate. (2S, 5R)-5-[(benzyloxy) amino] piperidine-2-formate II is used as a raw material and reacts with Boc-4-aminopiperidine III in the presence of an accelerant to generate 4-((2S, 5R)-((benzyloxy) amino) piperidine-2-formamide) piperidine-1-tert-butyl formate I. The method has the advantages of readily available raw materials, mild reaction conditions, high reaction selectivity, high reaction speed, few impurities and the like.

PREPARATION OF TERT-BUTYL 4-((1R,2S,5R)-6- (BENZYLOXY)-7-0X0-1,6-DIAZABICYCL0[3.2.I]OCTANE-2- CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE

A process for the preparation of N-protected 6-(piperidin-4-ylcarbamoyl)piperidin-3-yl sulfonates of Formula (III): which comprises contacting a lactone of Formula (II): with an azacycloalkylamine of formula (II-Am): followed by contact with a sulfonyl halide of formula (II-Su): R4-SO2W (II-Su) in the presence of tertiary amine base, wherein PG1 and PG2 are amine protective groups; k, p and q are 0, 1, or 2, and W, R2, R3, R4, R5, R6, R7, R8, and R9 are defined herein. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.