1416134-44-5

Basic information

• Product Name: (x)C₂H₂O₄*C₂₀H₂₄N₂O₃
• CAS NO: 1416134-44-5
• Mol File: 1416134-44-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (x)C₂H₂O₄*C₂₀H₂₄N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: (x)C₂H₂O₄*C₂₀H₂₄N₂O₃(1416134-44-5)
• EPA Substance Registry System: (x)C₂H₂O₄*C₂₀H₂₄N₂O₃(1416134-44-5)

Safety Data

• Hazardous Substances Data: 1416134-44-5(Hazardous Substances Data)

Usage

General Description

The chemical compound (x)C2H2O4*C20H24N2O3 is a complex substance that consists of two main components: oxalic acid (C2H2O4) and a compound with the molecular formula C20H24N2O3. Oxalic acid is a strong organic acid that is commonly found in many plants and vegetables, and it is used in various industrial processes and as a cleaning agent. The second component, C20H24N2O3, is a large organic compound that contains carbon, hydrogen, nitrogen, and oxygen atoms. (x)C₂H₂O₄*C₂₀H₂₄N₂O₃ could be a variety of different substances, including a pharmaceutical drug, a natural product, or a synthetic compound. The exact identity and properties of the compound would depend on the specific value of "x" and the ratio of the two components.

Upstream product

• 1171080-44-6 (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid benzyl ester 
• 144-62-7 oxalic acid 
• 1133931-68-6 (2S)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester 
• 1133931-74-4 (2S)-5-(benzyloxyimino)-piperidine-2-carboxylic acid benzyl ester 
• 6153-56-6 oxalic acid dihydrate 
• 1133931-73-3 benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate 
• 113400-36-5 benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate 

Downstream Products

• 1174020-25-7 (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 
• 1171080-44-6 (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid benzyl ester 
• 1401540-62-2 (2S,5S)-5-(benzyloxyamino)-piperidine-2-carboxylic acid benzyl ester 

Relevant articles and documents

Method for synthesizing avibactam intermediate compound

The invention relates to a method for synthesizing an avibactam intermediate compound. The specific synthetic route of the method is as described in the specification. According to a technical schemeof the invention, no precious metal catalyst is used, and no heavy metal pollution is produced; high yield and low cost are realized; and the method is mild in reaction condition and friendly to environment, and can realize industrial production.

B-LACTAMASE INHIBITOR AND APPLICATION THEREOF

The present invention relates to a compound of Formula (I)-(IV) useful as β-lactamase inhibitor, a pharmaceutically acceptable salt, ester, solvate or stereoisomer thereof, wherein R1, R2, M and ring A have definitions as those in the specification. The present invention further relates to methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and uses of these compounds. For example, the compounds of the present invention can be used as β-lactamase inhibitors, for treatment and/or prophylaxis of diseases caused by bacterial infections, solving drug-resistance problems caused by β-lactamases, especially bacterial drug-resistant diseases caused by type B metallo-β-lactamases.

Development of a Manufacturing Route to Avibactam, a β-Lactamase Inhibitor

Process development work to provide an efficient, robust, and cost-effective manufacturing route to avibactam, a β-lactamase inhibitor is presented herewith. Aspects of this optimization work include the counterintuitive introduction of a protecting group to effect a difficult urea formation and the use of controlled feed hydrogenation conditions to facilitate an elegant one pot debenzylation and sulfation reaction. Overall, the commercial process delivers avibactam in much improved yield with significant reduction in the environmental footprint.