1171920-17-4

Usage

Uses

Used in Pharmaceutical Research:
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde is utilized as a key intermediate in the organic synthesis of various pharmaceutical drugs. Its presence in the molecular structure of these drugs can contribute to their therapeutic effects and properties.
Used in Medicinal Chemistry Research:
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde serves as a valuable tool in medicinal chemistry research, where it is used to explore the potential of new drug candidates. Its unique structure allows for the investigation of its interactions with biological targets, which can lead to the discovery of new therapeutic agents.
Used in Drug Discovery:
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde is employed in drug discovery processes to identify and develop new drugs. Its potential applications in the treatment of neurological disorders and cancer make it a promising candidate for further research and development.
Used in the Development of Neurological Disorder Treatments:
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde is considered for its potential role in the development of new drugs aimed at treating neurological disorders. Its unique structure and biological activity may offer new avenues for therapeutic intervention in these conditions.
Used in Cancer Treatment Research:
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde is also being explored for its potential applications in the development of new cancer treatments. Its incorporation into drug molecules could lead to the creation of novel anticancer agents with improved efficacy and reduced side effects.

Upstream product

• 866319-00-8 5-fluoro-1H-pyrrolo[2,3‐b]pyridine 
• 4885-02-3 Dichloromethyl methyl ether 
• 68-12-2 N,N-dimethyl-formamide 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 1428969-87-2 1-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-((3-methoxyphenyl)amino)-2-phenylethanone 
• 1428969-93-0 2-((3,5-dimethoxyphenyl)amino)-1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-phenylethanone 

Relevant academic research and scientific papers

Structural Diversification of Hapalindole and Fischerindole Natural Products via Cascade Biocatalysis

Hapalindoles and related compounds (ambiguines, fischerindoles, welwitindolinones) are a diverse class of indole alkaloid natural products. They are typically isolated from the Stigonematales order of cyanobacteria and possess a broad scope of biological activities. Recently the biosynthetic pathway for assembly of these metabolites has been elucidated. In order to generate the core ring system, l-tryptophan is converted into the cis-indole isonitrile subunit before being prenylated with geranyl pyrophosphate at the C-3 position. A class of cyclases (Stig) catalyzes a three-step process, including a Cope rearrangement, 6-exo-trig cyclization, and electrophilic aromatic substitution, to create a polycyclic core. The formation of the initial alkaloid is followed by diverse late-stage tailoring reactions mediated by additional biosynthetic enzymes to give rise to a wide array of structural variations observed in this compound class. Herein, we demonstrate the versatility and utility of the Fam prenyltransferase and Stig cyclases toward the core structural diversification of this family of indole alkaloids. Through the synthesis of cis-indole isonitrile subunit derivatives, and with the aid of protein engineering and computational analysis, we have employed cascade biocatalysis to generate a range of derivatives and gained insights into the basis for substrate flexibility in this system.

VIRAL REPLICATION INHIBITORS

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7

The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.