117226-91-2Relevant academic research and scientific papers
Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones
Zhang, Li Jun,Zhang, Xiang,You, Zhen Sheng,Li, Heng,Feng, Tian,Wang, Wei Li
, p. 2081 - 2086 (2016/10/18)
Abstract: Chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be a high efficient heterogeneous catalyst to solve this problem. Under Zn–SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production. Graphical Abstract: Improving chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be efficient heterogeneous catalyst to solve this problem. Under Zn-SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.[Figure not available: see fulltext.]
Synthesis of 3,4-dihydropyridin-2-one derivatives in convergent mode applying bio catalyst vitamin B1 and polymer supported catalyst PEG-SO3H from two different sets of building blocks
Pradhan, Koyel,Bhattacharyya, Pranabes,Paul, Sanjay,Das, Asish R.
, p. 5840 - 5844,5 (2020/08/20)
Two highly efficient, green protocols have been developed for the synthesis of 3,4-dihydropyridin-2-one derivatives from different starting materials exploring two reaction specific catalysts, vitamin B1 (VB 1), and PEG-SO3/sub
Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus in aqueous media
Bhattacharyya, Pranabes,Pradhan, Koyel,Paul, Sanjay,Das, Asish R.
supporting information; experimental part, p. 4687 - 4691 (2012/09/05)
A green and highly efficient protocol has been developed for the synthesis of 4H-pyran scaffolds installing a one-pot three-component coupling reaction of an aldehyde, malononitrile, and a 1,3-diketo compound using nano structured ZnO as the catalyst in a
Imidazole-catalyzed three-component cascade reaction for the facile synthesis of highly substituted 3,4-dihydropyridin-2-one derivatives
Liu, Zhiqiang,Tan, Lu,Wu, Qi,Lin, Xianfu
, p. 2343 - 2348,6 (2012/12/12)
A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin- 2-ones from the condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A series of aldehydes and 1,3-dicarbonyl compounds were employed to examine the scope of substrates for this protocol. This reaction proceeded through the formation of one ring and four new bonds (two Ci￡C, one Ci￡N, one Ci￡C) via the sequence involving Knoevenagel condensation, Michael addition and intramolecular cyclization with moderate to excellent yields. All new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS. Copyright
A Facile Preparation of Alkylpyridines from Aminopyrans
Marugan, Monica M.,Martin, Nazario,Seoane, Carlos,Soto, Jose L.
, p. 145 - 150 (2007/10/02)
Alkyl-substituted pyridinones 4, pyrones 5, dihydropyridinones 2, and pyridines 6 are prepared by means of ring transformation of alkyl-substituted 2-amino-4H-purans 1.Some open-chain intermediates (3) as well as the aromatization of the partially unsatur
