1172583-80-0

Upstream product

• 446312-38-5 {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 328236-47-1 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol 
• 328236-46-0 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol 
• 328236-45-9 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol 
• 328236-44-8 2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde 
• 851227-21-9 [4-(4-hydroxy-3-iodo-5-isopropylbenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 328236-42-6 4-bromo-2-isopropyl phenyl methoxymethyl ether 
• 26307-50-6 4-bromo-2-isopropyl-phenol 
• 88-69-7 2-(1-methylethyl)phenol 
• 863639-45-6 methyl 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetate 
• 446312-35-2 [4-(3-iodo-5-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 851227-20-8 [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 

Relevant academic research and scientific papers

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity

We have synthesized and established the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed during the synthesis of NH-3. Understanding the mechanism of its formation has enabled isotope (D) labeling. We further devel

An improved synthesis of (4-{4-hydroxy-3-isopropyl-5-[(4-nitrophenyl) ethynyl] benzyl}-3,5-dimethylphenoxy)acetic acid (NH-3)

Sonogashira coupling of methyl {4-[3-iodo-5-isopropyl-4-(methoxymethoxy) benzyl]-3,5-dimethylphenoxy}acetate with (trimethylsilyl)acetylene afforded the corresponding (trimethylsilyl) ethynyl derivative in quantitative yield. Copper-free palladium-catalyz