446312-38-5

Upstream product

• 328236-47-1 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol 
• 328236-45-9 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol 
• 328236-44-8 2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde 
• 851227-21-9 [4-(4-hydroxy-3-iodo-5-isopropylbenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 328236-42-6 4-bromo-2-isopropyl phenyl methoxymethyl ether 
• 26307-50-6 4-bromo-2-isopropyl-phenol 
• 88-69-7 2-(1-methylethyl)phenol 
• 863639-45-6 methyl 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetate 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 446312-35-2 [4-(3-iodo-5-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 851227-20-8 [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 636-98-6 p-nitrobenzene iodide 
• 1172583-79-7 methyl (4-{3-isopropyl-4-(methoxymethoxy)-5-[(trimethylsilyl)ethynyl]benzyl}-3,5-dimethylphenoxy)acetate 

Downstream Products

• 1172583-80-0 2-(4-(3-isopropyl-4-(methoxymethoxy)-5-((4-nitrophenyl)ethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid 
• 446312-39-6 {4-[4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 

Relevant academic research and scientific papers

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity

We have synthesized and established the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed during the synthesis of NH-3. Understanding the mechanism of its formation has enabled isotope (D) labeling. We further devel

An improved synthesis of (4-{4-hydroxy-3-isopropyl-5-[(4-nitrophenyl) ethynyl] benzyl}-3,5-dimethylphenoxy)acetic acid (NH-3)

Sonogashira coupling of methyl {4-[3-iodo-5-isopropyl-4-(methoxymethoxy) benzyl]-3,5-dimethylphenoxy}acetate with (trimethylsilyl)acetylene afforded the corresponding (trimethylsilyl) ethynyl derivative in quantitative yield. Copper-free palladium-catalyz

Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment

Recent efforts have focused on the design and synthesis of thyroid hormone (T3) antagonists as potential therapeutic agents and chemical probes to understand hormone-signaling pathways. We previously reported the development of novel first-gene