1172623-96-9

Basic information

• Product Name: tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate
• Synonyms: tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate;tert-Butyl [1-(2,5-difluorophenyl)-1-oxo-4-pentyn-2-yl]carbamate;Carbamic acid, N-[1-(2,5-difluorobenzoyl)-3-butyn-1-yl]-, 1,1-dimethylethyl ester
• CAS NO: 1172623-96-9
• Molecular Formula: C₁₆H₁₇F₂NO₃
• Molecular Weight: 309.3078864
• Mol File: 1172623-96-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 429.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.199±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.20±0.46(Predicted)
• CAS DataBase Reference: tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate(1172623-96-9)
• EPA Substance Registry System: tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate(1172623-96-9)

Safety Data

• Hazardous Substances Data: 1172623-96-9(Hazardous Substances Data)

Usage

Uses

tert-Butyl (1-(2,5-Difluorophenyl)-1-oxopent-4-yn-2-yl)carbamate is used as a reactant in the preparation of a highly functionalized tetrahydropyran DPP-4 inhibitor.

Upstream product

• 50428-03-0 D,L-propargylglycine 
• 61172-66-5 2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid 
• 171922-16-0 ethyl 2-[(diphenylmethylidene)amino]pent-4-ynoate 
• 167904-79-2 methyl (R,S)-2-(N-diphenylmethylidene)aminopent-4-ynoate 
• 100860-41-1 ethyl 2-aminopent-4-ynoate 
• 60468-36-2 α-chloro-2',5'-difluoroacetophenone 
• 540-36-3 para-difluorobenzene 
• 106-96-7 propargyl bromide 
• 6165-75-9 propargyl benzenesulfonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1172623-95-8 (±)-tert-butyl (1-(methoxy(methyl)amino)-1-oxopent-4-yn-2-yl)carbamate 
• 899819-34-2 (2,5-difluorophenyl)magnesium bromide 
• 399-94-0 2-bromo-1,4-difluorobenzene 

Downstream Products

• 1172623-98-1 tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbamate 
• 1172623-99-2 tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl]carbamate 
• 951127-25-6 N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester 

Relevant articles and documents

Ternary fused ring substituted six-membered ring derivatives and their use in medicine

The invention relates to a fused tricyclic substituted amino six-membered ring derivative and application thereof in medicine, particularly a fused tricyclic substituted amino six-membered ring derivative shown in a formula (I) or stereoisomers and pharmaceutically acceptable salts or pro-drugs of the derivative, a pharmaceutical composition comprising the derivative and use of the derivative in preparing a dipeptidyl peptidase IV (DPP-IV) inhibitor in medicine, wherein the substituents in the formula (I) are defined as in the description. The formula (I) is shown in the description.

AMINO PYRANOID RING DERIVATIVE AND COMPOSITION AND USE THEREOF

The present invention relates to an amino pyran ring derivative and a composition and use thereof, and in particular, to an amino pyran ring derivative represented by general formula (I) or a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition comprising the derivative, and their medical use in the manufacture of a di-peptidyl peptidase IV (DPP-IV) inhibitor, in formula (I) the substituents are defined the same as those in the specification.

Three-membered fused ring substituted amino six-membered ring derivative and medicine applications thereof relates to a three-membered fused ring substituted amino six-membered ring derivative as shown in the general formula

The present invention relates to a three-membered fused ring substituted amino six-membered ring derivative and medicine applications thereof, and more particularly to a three-membered fused ring substituted amino six-membered ring derivative as shown in the general formula (I) or a stereoisomer of the derivative, a pharmaceutically acceptable salt, a prodrug, a medicinal composition containing the derivative and an application of the derivative to preparation of the medicine, namely a dipeptidyl peptidase IV(DPP-IV) inhibitor, wherein the definitions of the various substituents in the general formula (I) are the same as those in the specification.