117269-54-2Relevant academic research and scientific papers
Design, synthesis, and evaluation of novel biarylpyrimidines: A new class of ligand for unusual nucleic acid structures
Wheelhouse, Richard T.,Jennings, Sharon A.,Phillips, Victoria A.,Pletsas, Dimitrios,Murphy, Peter M.,Garbett, Nichola C.,Chaires, Jonathan B.,Jenkins, Terence C.
, p. 5187 - 5198 (2008/04/18)
Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of dihalopyrimidines. Two ligand series are described based on
Biarylpyrimidines: a new class of ligand for high-order DNA recognition.
Murphy, Peter M,Phillips, Victoria A,Jennings, Sharon A,Garbett, Nichola C,Chaires, Jonathan B,Jenkins, Terence C,Wheelhouse, Richard T
, p. 1160 - 1161 (2007/10/03)
Biarylpyrimidines bearing omega-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachme
Binding of Unfused Aromatic Cations to DNA. The Influence of Molecular Twist on Intercalation
Wilson, D. David,Strekowski, Lucjan,Tanious, Farial A.,Watson, Rebecca A.,Mokrosz, Jerzy L.,et al.
, p. 8292 - 8299 (2007/10/02)
A new type of intercalator, I, and its nonintercalating analogue, 2, are both twisted about the torsional bonds joining the aromatic rings.Spectroscopic methods and MM2 calculations indicate that the twist for 2 is significantly greater than for 1 (48 deg
