117284-59-0

Basic information

• Product Name: 2-(2,2-Difluoro-cyclopropyl)-ethanol
• Synonyms: 2-(2,2-Difluoro-cyclopropyl)-ethanol;MFCD18250117;2-(2,2-difluorocyclopropyl)ethan-1-ol;Cyclopropaneethanol, 2,2-difluoro-
• CAS NO: 117284-59-0
• Molecular Formula: C₅H₈F₂O
• Molecular Weight: 122.1132264
• Mol File: 117284-59-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,2-Difluoro-cyclopropyl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-Difluoro-cyclopropyl)-ethanol(117284-59-0)
• EPA Substance Registry System: 2-(2,2-Difluoro-cyclopropyl)-ethanol(117284-59-0)

Safety Data

• Hazardous Substances Data: 117284-59-0(Hazardous Substances Data)

Usage

General Description

2-(2,2-Difluoro-cyclopropyl)-ethanol is a chemical compound with the molecular formula C5H8F2O. It is a colorless liquid with a molecular weight of 130.11 g/mol. 2-(2,2-Difluoro-cyclopropyl)-ethanol is used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical products. It is also used in the production of agrochemicals and other specialty chemicals. 2-(2,2-Difluoro-cyclopropyl)-ethanol is known for its unique chemical structure and properties, making it a valuable ingredient in the manufacturing of various chemical products. It is important to handle this compound with care and follow proper safety precautions when working with it in a laboratory or industrial setting.

Upstream product

• 18203-32-2 3-butenyl benzoate 
• 117388-09-7 2-(2,2-difluorocyclopropyl)ethyl benzoate 

Downstream Products

• 123131-76-0 2-(2,2-Difluorocyclopropyl)ethyl 3,4-dichlorophenylcarbamate 
• 123131-67-9 2-(2,2-difluorocyclopropyl)-acetic acid 

Relevant articles and documents

Rate constant for the ring opening of the 2,2-difluorocyclopropylcarbinyl radical

(figure presented) The rate constant for the unimolecular ring opening of the 2,2-difluorocyclopropylcarbinyl radical was determined via its competitive bimolecular trapping by TEMPO. The value of this rate constant (3.4 × 1011 s-1 a

Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3/NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.