681853-99-6Relevant academic research and scientific papers
Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity
Choi, Won Jun,Chung, Hwa-Jin,Chandra, Girish,Alexander, Varughese,Zhao, Long Xuan,Lee, Hyuk Woo,Nayak, Akshata,Majik, Mahesh S.,Kim, Hea Ok,Kim, Jin-Hee,Lee, Young B.,Ahn, Chang H.,Lee, Sang Kook,Jeong, Lak Shin
, p. 4521 - 4525 (2012/08/13)
On the basis of the potent biological activity of cyclopentenyl- pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range of
Stereoselective synthesis of 3-hydroxymethyl-D-cyclopentenone, the versatile intermediate for the synthesis of carbocyclic nucleosides
Choi, Won Jun,Moon, Hyung Ryong,Kim, Hea Ok,Ko, Young Mi,Kim, Hye Jin,Lee, Jeong A.,Lee, Kang Man,Yun, Mi Kyung,Shin, Dae Hong,Chun, Moon Woo,Sheen, Yhun Y.,Kim, Kilhyoun,Jeong, Lak Shin
, p. 611 - 613 (2008/02/04)
The preparative and stereoselective synthesis (45-50% overall yields, >50 g scale) of the key carbasugars 7a-d was achieved from D-ribose via stereoselective Grignard reaction and oxidative rearrangement as key reactions. Copyright Taylor & Francis, Inc.
Preparative and Stereoselective Synthesis of the Versatile Intermediate for Carbocyclic Nucleosides: Effects of the Bulky Protecting Groups to Enforce Facial Selectivity
Choi, Won Jun,Moon, Hyung Ryong,Kim, Hea Ok,Yoo, Byul Nae,Lee, Jeong A.,Shin, Dae Hong,Jeong, Lak Shin
, p. 2634 - 2636 (2007/10/03)
The preparative and stereoselective synthesis (45-50% overall yields) of the target compound 17 has been accomplished from D-ribose. The bulky protecting groups such as TBDPS and Trityl enforced the facial selectivity during Grignard reaction to give the
