1174761-01-3Relevant academic research and scientific papers
One-Pot Approach for the Synthesis of Bis-indole-1,4-disubstituted-1,2,3-triazoles
Saehlim, Natthiya,Kasemsuk, Teerapich,Sirion, Uthaiwan,Saeeng, Rungnapha
, p. 13233 - 13242 (2018)
A new strategy for the synthesis of bis-indoletriazoles was developed using a sequential one-pot four-step procedure via I2 and H2SO4-SiO2 catalyzed Friedel-Crafts reactions of indole with aldehyde followed by N-alkylation with propargyl bromide, azidation, and copper(I)-catalyzed azide alkyne cycloaddition (CuAAC). The reaction proceeded smoothly at room temperature in a short time, and a series of bis-indoletriazoles were obtained in good to excellent yields proving the generality of this one-pot methodology.
Regioselective synthesis and biological evaluation of bis(indolyl)methane derivatized 1,4-disubstituted 1,2,3-bistriazoles as anti-infective agents
Damodiran,Muralidharan,Perumal, Paramasivan T.
experimental part, p. 3611 - 3614 (2010/03/31)
The regioselective synthesis of 1,4-disubstituted 1,2,3-bistriazoles from a variety of N-propargyl bis(indolyl)methanes with sodium azide using CuI as the catalyst in polyethyleneglycol-400 is reported. This process is of considerable synthetic advantages
