1174917-95-3Relevant academic research and scientific papers
BICYCLIC MORPHOLINO COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
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, (2016/08/03)
The present invention provides bicyclic morpholino compounds and oligomeric compounds prepared therefrom. More particularly, incorporation of one or more of the bicyclic morpholino compounds into an oligomeric compound is expected to enhance one or more p
SUBSTITUTED 2 '-AMINO AND 2 '-THIO-BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
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, (2012/01/05)
Provided herein are 2'-amino and 2'-thio bicyclic nucleosides and oligomenc compounds prepared therefrom. The novel bicyclic nucleosides provided herein are expected to be useful for enhancing one or more properties of the oligomeric compounds they are in
Synthesis and biophysical evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl nucleic acid analogues
Seth, Punit P.,Vasquez, Guillermo,Allerson, Charles A.,Berdeja, Andres,Gaus, Hans,Kinberger, Garth A.,Prakash, Thazha P.,Migawa, Michael T.,Bhat, Balkrishen,Swayze, Eric E.
experimental part, p. 1569 - 1581 (2010/06/12)
"Chemical Equation Presented" We have recently shown that combining the structural elements of 2′O-methoxyethyl (MOE) and locked nucleic acid (LNA) nucleosides yielded a series of nucleoside modifications (cMOE, 2′,4′-constrained MOE; cEt, 2′,4′-constrain
6-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
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Page/Page column 23-24, (2010/11/28)
The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
