1174930-71-2

Basic information

• Product Name: VX-770
• CAS NO: 1174930-71-2
• Molecular Formula: C24H28N2O3
• Molecular Weight: 392.49072
• Mol File: 1174930-71-2.mol
• Article Data: 45

Chemical Properties

• Appearance: /
• CAS DataBase Reference: VX-770(CAS DataBase Reference)
• NIST Chemistry Reference: VX-770(1174930-71-2)
• EPA Substance Registry System: VX-770(1174930-71-2)

Safety Data

• Hazardous Substances Data: 1174930-71-2(Hazardous Substances Data)

Upstream product

• 53977-02-9 1-benzyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 1622228-86-7 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 445-29-4 o-fluoro-benzoic acid 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1207748-75-1 ethyl 3-(benzylamino)-2-(2-fluorobenzoyl)-2-propenoate 
• 108-88-3 toluene 
• 1182822-31-6 5-amino-2,4-di-tert-butylphenyl methyl carbonate 
• 765222-35-3 4-chloroquinoline-3-carbonyl chloride 
• 873055-58-4 5-amino-2-4-di-tert-butyl-phenol 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 873055-57-3 2,4-di-tert-butyl-5-nitro-phenol 
• 52119-39-8 ethyl (2-nitrobenzoyl)acetate 
• 106718-56-3 diethyl 2-(2-nitro-benzoyl)malonate 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 1246213-23-9 N-(2-(tert-butyl)-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1246213-24-0 2-(5-tert-butyl-2-hydroxy-4-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl)-2-methylpropanoic acid 
• 1134821-99-0 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide propylene glycol solvate 

Relevant articles and documents

An Efficient Synthesis of Ivacaftor

New and practical synthetic route of ivacaftor is described on a grams scale. An electrophilic addition of two t-butyl groups to the aromatic ring is adopted to prepare 5-amino-2,4-di-t-butylphenol in 61% yield over three steps with 98.1% purity (high-performance liquid chromatography). An intramolecular cyclization of ethyl 3-(2-aminophenyl)-3-oxo-propanoate with dimethylformamide-dynamic mechanical analysis is used to prepare 4-oxo-1,4-dihydroquinoline-3-carboxylic acid in 54% yield over four steps. Ivacaftor is obtained by condensation of the two parts in 71% yield with 99.1% purity (high-performance liquid chromatography).

Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

This application describes methods of treating cystic fibrosis comprising administering Compound I:, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising any of the foregoing.