35975-86-1

Basic information

• Product Name: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS NO: 35975-86-1
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.29
• Mol File: 35975-86-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 459.1°C at 760 mmHg
• Flash Point: 231.5°C
• Density: 1.358g/cm³
• Vapor Pressure: 3.17E-09mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(35975-86-1)
• EPA Substance Registry System: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(35975-86-1)

Safety Data

• Hazardous Substances Data: 35975-86-1(Hazardous Substances Data)

Usage

General Description

1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a chemical compound with potential pharmaceutical applications. It is a derivative of quinoline and contains a benzyl group, a carbonyl group, and a carboxylic acid group. 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid has been studied for its potential as a therapeutic agent, with research indicating that it may have antimicrobial, anti-inflammatory, and antitumor properties. Additionally, it has been investigated for its potential as an inhibitor of certain enzymes and for its ability to modulate biological processes. Its unique structure and potential medicinal properties make it a subject of interest in the field of pharmaceutical chemistry.

Upstream product

• 100-39-0 benzyl bromide 
• 52980-28-6 ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 53977-02-9 1-benzyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 54535-22-7 diethyl (anilinomethylene)malonate 
• 289706-52-1 ethyl 2-(2',2',2'-trichloro)ethylidene-3-oxo-3-(2''-chlorophenyl)propionate 
• 289706-56-5 ethyl (2'-chlorophenyl)-3-oxo-2-(N-benzylamino)methylene propionate 
• 19112-35-7 ethyl (2-chlorobenzoyl)acetate 
• 62-53-3 aniline 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 445-29-4 o-fluoro-benzoic acid 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1207748-75-1 ethyl 3-(benzylamino)-2-(2-fluorobenzoyl)-2-propenoate 
• 1353669-36-9 methyl 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 61707-79-7 1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester 

Downstream Products

• 1622228-86-7 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 873054-44-5 ivacaftor 
• 91420-16-5 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 

Relevant articles and documents

Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies

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AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE

The present invention provides a compound of formula I, a tautomer thereof, or a pharmaceutically acceptable salt or N-oxide thereof for use in the treatment or prevention of a cardiovascular disease or of an inflammatory disease or condition:

A PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES

The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.