1175184-76-5Relevant academic research and scientific papers
Mild decarboxylative allylation of coumarins
Jana, Ranjan,Trivedi, Rushi,Tunge, Jon A.
, p. 3434 - 3436 (2009)
Allyl esters of 3-carboxylcoumarins undergo facile decarboxylative coupling at just 25-50 °C. This represents the first extension of decarboxylative C-C bond-forming reactions to the coupling of aromatics with sp 3-hybridized electrophiles. Finally, the same concept can be applied to the sp2-sp3 couplings of pyrones and flavones. Thus, a variety of biologically important heteroaromatics can be readily functionalized without the need for strong bases or stoichiometric organometallics that are typically required for more standard cross-coupling reactions.
