117571-36-5

Basic information

• Product Name: <4-methyl-2-(phenylmethoxy)phenyl>acetonitrile
• Synonyms: <4-methyl-2-(phenylmethoxy)phenyl>acetonitrile
• CAS NO: 117571-36-5
• Molecular Weight: 237.301
• Mol File: 117571-36-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: <4-methyl-2-(phenylmethoxy)phenyl>acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: <4-methyl-2-(phenylmethoxy)phenyl>acetonitrile(117571-36-5)
• EPA Substance Registry System: <4-methyl-2-(phenylmethoxy)phenyl>acetonitrile(117571-36-5)

Safety Data

• Hazardous Substances Data: 117571-36-5(Hazardous Substances Data)

Upstream product

• 117571-34-3 4-methyl-2-(phenylmethoxy)benzenemethanol 
• 433712-96-0 2-benzyloxy-4-methyl-benzoylchloride 
• 117571-33-2 4-methyl-2-(phenylmethoxy)benzoic acid 
• 75-09-2 dichloromethane 
• 117571-35-4 1-(bromomethyl)-4-methyl-2-(phenylmethoxy)benzene 
• 773837-37-9 sodium cyanide 
• 100-39-0 benzyl bromide 
• 50-85-1 2-hydroxy-p-toluic acid 
• 143-33-9 sodium cyanide 

Downstream Products

• 38692-77-2 (2-hydroxy-4-methylphenyl)acetic acid 
• 117571-38-7 C₉H₈O₃^(2-)*2Na⁽¹⁺⁾ 
• 129833-38-1 2-(2-Carboxymethyl-5-methyl-phenoxy)-3-methyl-benzoic acid 
• 117571-37-6 <4-methyl-2-(phenylmethoxy)phenyl>acetic acid 

Relevant articles and documents

N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids

Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice.To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions have been prepared and evaluated.The 5,6-disubstituted compounds in particular show consistently high levels of both dose potency and activity, suggesting this is the optimal configuration among substituted 9-oxo-9H-xanthene-4-acetic acids.The 5,6-dimethyl and 5-methyl-6-methoxy are the most effective analogues, showing in vivo colon 38 activity comparable to that of FAA at 10-15-fold lower doses and superior activity to FAA at the respective optimal doses, and the former has been selected for detailed evaluation.