117710-90-4Relevant academic research and scientific papers
TfOH-Promoted Reaction of 2,4-Diaryl-1,1,1-Trifluorobut-3-yn-2-oles with Arenes: Synthesis of 1,3-diaryl-1-CF3-indenes and versatility of the reaction mechanisms
Zerov, Aleksey V.,Kazakova, Anna N.,Boyarskaya, Irina A.,Panikorovskii, Taras L.,Suslonov, Vitalii V.,Khoroshilova, Olesya V.,Vasilyev, Aleksander V.
, (2018)
The TfOH-mediated reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-oles (CF3-substituted diaryl propargyl alcohols) with arenes in CH2Cl2 afford 1,3-diaryl-1-CF3-indenes in yields up to 84%. This new process for synthesis of such CF3-indenes is complete
Acidic Zeolite-Catalyzed Reaction of 2,4-Diaryl-1,1,1-trifluorobut-3-yn-2-ols with Benzene. A New Synthesis of 1,3-Diaryl-1-trifluoromethylindenes
Nursahedova,Zerov,Vasilyev
, p. 1764 - 1771 (2018)
Reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-ols with benzene in the presence of HUSY acidic zeolite (CBV-720) at 100°C in 1 h (glass high-pressure reactor) led to the formation of 1,3-diaryl-1-trifluoromethylindenes in 39–92% yield. A probable react
Bimetallic copper and zinc-catalyzed oxidative cycloaddition of 3-aminopyridazines and nitriles: A direct synthesis of 1,2,4-triazolo[1,5-: B] pyridazines via C-N and N-N bond-forming process
Mu, Qiu-Chao,Lv, Ji-Yuan,Chen, Mu-Yi,Bai, Xing-Feng,Chen, Jing,Xia, Chun-Gu,Xu, Li-Wen
, p. 37208 - 37213 (2017)
One-pot formation of the 1,2,4-triazolo[1,5-b]pyridazine nucleus and its derivatives is presented in this manuscript, in which the desired targets are offered easily via cooperative Cu(i) and Zn(ii)-catalyzed tandem C-N addition and subsequent I2/KI-mediated intramolecular oxidative N-N bond formation.
Au-Ag synergistic effect in CF3-ketone alkynylation catalyzed by precise nanoclusters
Sun, Lili,Shen, Kangqi,Sheng, Hongting,Yun, Yapei,Song, Yongbo,Pan, Dianhui,Du, Yuanxin,Yu, Haizhu,Chen, Mingyang,Zhu, Manzhou
, p. 220 - 225 (2019)
Despite the widespread use of bimetallic nanomaterial catalysts, a molecular-level understanding of the synergistic effects is unclear, limiting our ability to pre-design “tailor-made” bimetallic catalysts. We chose bimetallic Au1Ag24/sub
Copper(I) alkoxide-catalyzed alkynylation of trifluoromethyl ketones
Motoki, Rie,Kanai, Motomu,Shibasaki, Masakatsu
, p. 2996 - 3000 (2007)
A general method for direct alkynylation of trifluoromethyl ketones was developed by using CuO'Bu-xantphos or phenanthroline complexes as catalysts. The ligands significantly enhanced the catalyst activity. In addition, KOTf, generated in the catalyst pre
Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones
Ramasamy, Manickavasakam,Lin, Hui-Chang,Kuo, Sheng-Chu,Hsieh, Min-Tsang
supporting information, p. 356 - 360 (2019/02/12)
A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi
Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP
No?l, Florent,Vukovi?, Vuk D.,Yi, Jing,Richmond, Edward,Kravljanac, Pavle,Moran, Joseph
, p. 15926 - 15947 (2019/12/25)
A general method to access CF3-substituted allenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent is described. By tuning the reaction time and temperature, the obtained allenes rearr
Borazine-CF3? Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation
Geri, Jacob B.,Wade Wolfe, Michael M.,Szymczak, Nathaniel K.
supporting information, p. 1381 - 1385 (2018/01/15)
A fluoroform-derived borazine CF3? transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C?H and C?X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF3? transfer, and cation modification afforded a reagent with enhanced stability.
Gold-catalyzed synthesis of β-trifluoromethylated α,β-unsaturated ketones from CF3-substituted propargylic carboxylates and their reactivity in Diels-Alder reactions
Boreux, Arnaud,Lambion, Aubin,Campeau, Dominic,Sanita, Marina,Coronel, Ruben,Riant, Olivier,Gagosz, Fabien
supporting information, p. 5232 - 5239 (2018/06/01)
The synthesis of fluorinated synthetic intermediates has become a field of intense research in organic chemistry. In this article, we report the application of a gold-catalyzed rearrangement to the synthesis of β-trifluoromethylated α,β-unsaturated ketone
A simple efficient method of preparing efavirenz intermediates
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Paragraph 0014-0016, (2018/02/04)
The invention relates to a method for simply and efficiently preparing efavirenz intermediates, which belongs to the technical field of organic compound catalytic chemistry. The method is used for the high-yield preparation of a series of efavirenz interm
