117710-90-4

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 18402-75-0 1-triethoxysilyl-2-phenylacetylene 
• 536-74-3 phenylacetylene 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 58518-08-4 1,1,1-trifluoro-4-phenylbut-3-yn-2-one 
• 100-58-3 phenylmagnesium bromide 
• 3240-11-7 Phenylacetylene-d1 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 98-88-4 benzoyl chloride 
• 75-46-7 trifluoromethan 

Downstream Products

• 1397746-36-9 6-methyl-2,4-diphenyl-2-(triflouromethyl)-2H-chromene 
• 146801-19-6 4,4,4-trifluoro-3-hydroxy-1,3-diphenyl-1-butanone 

Relevant academic research and scientific papers

TfOH-Promoted Reaction of 2,4-Diaryl-1,1,1-Trifluorobut-3-yn-2-oles with Arenes: Synthesis of 1,3-diaryl-1-CF3-indenes and versatility of the reaction mechanisms

The TfOH-mediated reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-oles (CF3-substituted diaryl propargyl alcohols) with arenes in CH2Cl2 afford 1,3-diaryl-1-CF3-indenes in yields up to 84%. This new process for synthesis of such CF3-indenes is complete

Acidic Zeolite-Catalyzed Reaction of 2,4-Diaryl-1,1,1-trifluorobut-3-yn-2-ols with Benzene. A New Synthesis of 1,3-Diaryl-1-trifluoromethylindenes

Reactions of 2,4-diaryl-1,1,1-trifluorobut-3-yn-2-ols with benzene in the presence of HUSY acidic zeolite (CBV-720) at 100°C in 1 h (glass high-pressure reactor) led to the formation of 1,3-diaryl-1-trifluoromethylindenes in 39–92% yield. A probable react

Bimetallic copper and zinc-catalyzed oxidative cycloaddition of 3-aminopyridazines and nitriles: A direct synthesis of 1,2,4-triazolo[1,5-: B] pyridazines via C-N and N-N bond-forming process

One-pot formation of the 1,2,4-triazolo[1,5-b]pyridazine nucleus and its derivatives is presented in this manuscript, in which the desired targets are offered easily via cooperative Cu(i) and Zn(ii)-catalyzed tandem C-N addition and subsequent I2/KI-mediated intramolecular oxidative N-N bond formation.

Au-Ag synergistic effect in CF3-ketone alkynylation catalyzed by precise nanoclusters

Despite the widespread use of bimetallic nanomaterial catalysts, a molecular-level understanding of the synergistic effects is unclear, limiting our ability to pre-design “tailor-made” bimetallic catalysts. We chose bimetallic Au1Ag24/sub

Copper(I) alkoxide-catalyzed alkynylation of trifluoromethyl ketones

A general method for direct alkynylation of trifluoromethyl ketones was developed by using CuO'Bu-xantphos or phenanthroline complexes as catalysts. The ligands significantly enhanced the catalyst activity. In addition, KOTf, generated in the catalyst pre

Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP

A general method to access CF3-substituted allenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent is described. By tuning the reaction time and temperature, the obtained allenes rearr

Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones

A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi

Gold-catalyzed synthesis of β-trifluoromethylated α,β-unsaturated ketones from CF3-substituted propargylic carboxylates and their reactivity in Diels-Alder reactions

The synthesis of fluorinated synthetic intermediates has become a field of intense research in organic chemistry. In this article, we report the application of a gold-catalyzed rearrangement to the synthesis of β-trifluoromethylated α,β-unsaturated ketone

A simple efficient method of preparing efavirenz intermediates

The invention relates to a method for simply and efficiently preparing efavirenz intermediates, which belongs to the technical field of organic compound catalytic chemistry. The method is used for the high-yield preparation of a series of efavirenz interm

Transition-Metal-Free Catalytic Formal Hydroacylation of Terminal Alkynes

Although hydroacylation is a very useful reaction for producing ketones from aldehydes with 100% atom efficiency, classical Rh-catalyzed hydroacylation presents several problems, including the need for transition metal catalysts, unwanted decarbonylation of aldehydes, and difficulty in regioselectivity control. However, formal hydroacylation utilizing the nucleophilicity of terminal alkynes can avoid these problems. In this work, we have achieved transition-metal-free formal hydroacylation of terminal alkynes using an Mg3Al-CO3-layered double hydroxide as a heterogeneous catalyst. This system was applicable to the efficient synthesis of α,β-unsaturated ketones with various substituents, and the catalyst can be reused without a significant loss of catalytic performance.