117781-09-6

Basic information

• Product Name: (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol
• CAS NO: 117781-09-6
• Molecular Formula: C₁₃H₁₉NO₄
• Molecular Weight: 253.2943
• Mol File: 117781-09-6.mol

Chemical Properties

• Boiling Point: 489.8°C at 760 mmHg
• Flash Point: 289.9°C
• Density: 1.386g/cm³
• Vapor Pressure: 2.07E-10mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol(117781-09-6)
• EPA Substance Registry System: (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol(117781-09-6)

Safety Data

• Hazardous Substances Data: 117781-09-6(Hazardous Substances Data)

Upstream product

• 3287-99-8 benzylamine hydrochloride 
• 55908-15-1 D-xylo-hexos-4-ulose 
• 117770-09-9 N-benzyl-2,3-bis-(O-tert-butyldimethylsilyl)-1,4-dideoxy-5,6-O-isopropylidene-1,4-imino-D-glucitol 
• 2782-07-2 D-galactono-1,4-lactone 
• 117803-74-4 2,3-bis-(O-tert-butyldimethylsilyl)-1,4-bis-O-(methanesulphonyl)-5,6-O-isopropylidene-D-galactitol 
• 117770-08-8 2,3-(bis-O-tert-butyldimethylsilyl)-5,6-O-isopropylidene-D-galactono-1,4-lactone 
• 117781-08-5 2,3-bis-(O-tert-butyldimethylsilyl)-5,6-O-isopropylidene-D-galactitol 
• 56710-46-4 5,6-O-isopropylidene-D-galactonic acid γ-lactone 

Relevant articles and documents

Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitors

Diabetes is a multi-factorial disorder that should be treated with multi-effective compounds. Here we describe the access to polyhydroxylated pyrrolidines, belonging to the D-gluco and D-galacto series, through aminocyclization reactions of two differenti

POLYHYDROXYLATED PYRROLIDINES FROM SUGAR LACTONES: SYNTHESIS OF 1,4-DIDEOXY-1,4-IMINO-D-GLUCITOL FROM D-GALACTONOLACTONE AND SYNTHESES OF 1,4-DIDEOXY-1,4-IMINO-D-ALLITOL, 1,4-DIDEOXY-1,4-IMINO-D-RIBITOL, AND (2S,3R,4S)-3,4-DIHYDROXYPROLINE FROM D-GULONOLACTONE

The use of readily available sugar lactones in the synthesis of polyhydroxylated pyrrolidines is illustrated by the preparation of the glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-glucitol from D-galactonolactone and by the conversion of D-gulonolactone into 1,4-dideoxy-1,4-imino-D-allitol, 1,4-dideoxy-1,4-imino-D-ribitol, and (2S,3R,4S)-3,4-dihydroxyproline.