117788-15-5

Basic information

• Product Name: 1-benzyl-2,3-diphenyl-1H-indole
• Synonyms: 1-benzyl-2,3-diphenyl-1H-indole
• CAS NO: 117788-15-5
• Molecular Weight: 359.47
• Mol File: 117788-15-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-benzyl-2,3-diphenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2,3-diphenyl-1H-indole(117788-15-5)
• EPA Substance Registry System: 1-benzyl-2,3-diphenyl-1H-indole(117788-15-5)

Safety Data

• Hazardous Substances Data: 117788-15-5(Hazardous Substances Data)

Upstream product

• 1239-56-1 1-(2,3-diphenyl-1H-indol-1-yl)ethan-1-one 
• 3469-20-3 2,3-diphenyl-1H-indole 
• 5448-01-1 (2,3-diphenylindol-1-yl)phenylmethanone 
• 501-65-5 diphenyl acetylene 
• 603-35-0 triphenylphosphine 
• 100-46-9 benzylamine 
• 591-50-4 iodobenzene 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 62-53-3 aniline 
• 100-39-0 benzyl bromide 
• 614-31-3 N-benzyl-N-phenylhydrazine 
• 16547-01-6 N-Benzyl-N-methylaniline N-oxide 
• 1217-89-6 1-benzylisatin 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 3469-20-3 2,3-diphenyl-1H-indole 

Relevant articles and documents

Traceless directing strategy: Efficient synthesis of N-alkyl indoles via redox-neutral C-H activation

A general protocol for the synthesis of N-alkyl indoles has been developed via a redox neutral C-H activation strategy using a traceless nitroso directing group. A broad scope of substituted N-alkyl indoles has been prepared in good to excellent yields using a very simple Rh catalyst system in the absence of an external oxidant or any other additive. Good to excellent regioselectivity has been achieved for asymmetrically disubstituted acetylenes.

Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar-X σ-Bonds

We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C-H activation/amination of phosphine ligands with alkynes and aromatic/aliphatic amines for construction of structurally diverse indoles.

A Fast Track to Indoles and Annulated Indoles through ortho- vs ipso-Amination of Aryl Halides

A complementary site selective ortho- vs ipso-amination of aryl halides using non-electrophilic amine sources for construction of indole scaffolds is reported. A palladium-catalyzed alkyne insertion/C-H activation/palladacycle amination via merger of three easily diversified components including iodoarenes, alkynes, and amines delivers indoles with different substitution patterns even in gram scales. By employing ortho-bromoanilines, a consecutive annulative π-extension of indoles proceeds to construct indolo[1,2-f]phenanthridine scaffolds via four C-C and C-N bond formations in one pot.