1178515-21-3

Basic information

• Product Name: 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate
• Synonyms: 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate
• CAS NO: 1178515-21-3
• Molecular Weight: 698.727
• Mol File: 1178515-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate(1178515-21-3)
• EPA Substance Registry System: 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate(1178515-21-3)

Safety Data

• Hazardous Substances Data: 1178515-21-3(Hazardous Substances Data)

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 171284-84-7 (2R,5S)-2-t-butyl-1-aza-3-oxabicyclo<3.3.0>octane-4,8-dione 
• 1178515-20-2 C₂₇H₂₈F₆N₂O₂ 
• 104-15-4 toluene-4-sulfonic acid 
• 1214741-19-1 C₁₁H₁₅NO₄ 
• 1214741-20-4 C₁₂H₁₇NO₃ 
• 1214741-21-5 C₁₂H₁₉NO₃ 
• 1214741-22-6 (S)-5-oxo-2-vinylpyrrolidine-2-carbaldehyde 
• 1214741-13-5 C₂₀H₁₉F₆NO 
• 1214741-17-9 C₂₈H₂₅F₆NO₃ 

Downstream Products

• 858102-79-1 Rolapitant hydrochloride 

Relevant articles and documents

Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations