117953-29-4

Basic information

• Product Name: βa-naphthyl p-fluorophenyl sulphone
• Synonyms: βa-naphthyl p-fluorophenyl sulphone
• CAS NO: 117953-29-4
• Molecular Weight: 286.327
• Mol File: 117953-29-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: βa-naphthyl p-fluorophenyl sulphone(CAS DataBase Reference)
• NIST Chemistry Reference: βa-naphthyl p-fluorophenyl sulphone(117953-29-4)
• EPA Substance Registry System: βa-naphthyl p-fluorophenyl sulphone(117953-29-4)

Safety Data

• Hazardous Substances Data: 117953-29-4(Hazardous Substances Data)

Upstream product

• 462-06-6 fluorobenzene 
• 85-46-1 1-Naphthalenesulfonyl chloride 
• 93-11-8 2-Naphthalenesulfonyl chloride 
• 91-20-3 naphthalene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Relevant articles and documents

Isomerization-free sulfonylation and its application in the synthesis of PHA-565272A

FeCl3 catalyzed an isomerization-free Friedel-Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A.