118093-05-3Relevant academic research and scientific papers
Biomimetic Synthesis of Complex Flavonoids Isolated from Daemonorops “Dragon's Blood”
Schmid, Matthias,Trauner, Dirk
, p. 12332 - 12335 (2017/09/25)
The dragonbloodins are a pair of complex flavonoid trimers that have been isolated from the palm tree Daemonorops draco, one of the sources of the ancient resin known as “dragon's blood”. We present a short synthesis that clarifies their relative configur
Preparation methods of dracorhodin and salt and intermediates thereof and intermediate compounds
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Paragraph 0170; 0171; 0172; 0173, (2017/01/19)
The invention relates preparation methods of dracorhodin and salt and intermediates thereof and intermediate compounds. Synthesis of multifunctional group-substituted benzene ring core structures, that is, the intermediate compounds V, VI and VII is achieved by taking phloroglucinol trimethyl ether as a starting raw material, combining a formylation reaction, a Huang-Minlon reduction method, a methyl ether demethylation reaction, the reaction that benzyl is introduced onto phenolic hydroxyl through benzyl halogen, the reaction that methyl is introduced onto phenolic hydroxyl by taking dimethyl carbonate as a methylation reagent, a debenzylation reaction, a demethylation reaction and the like, utilizing the intramolecular hydrogen bond effect of formyl and phenolic hydroxyl on benzene rings and controlling the proper reaction conditions through proper combinations of the reactions and a protection-deprotection strategy. According to the method, dracorhodin and the salt thereof are synthesized by adopting the raw material which is low in cost, easy to obtain and low in toxicity, the process route is short, the cost is low, the chemical selectivity of all the steps is high, the total yield reaches up to about 10%, the process reproducibility is good, industrialization can be achieved, and the green and economical properties are achieved.
