1181812-29-2Relevant academic research and scientific papers
Phosphine-oxide-catalyzed Enantioselective Cross-aldol Reactions of Aldehydes with Trichlorosilane as Lewis Acid Promoter
Hanamure, Takuya,Kotani, Shunsuke,Mori, Yoshiki,Nakajima, Makoto
, p. 4780 - 4783 (2020/09/09)
A hypervalent silicon complex between trichlorosilane and a chiral phosphine oxide acts as an effective Lewis acid mediator that successfully promotes highly enantioselective cross-aldol reactions between two aldehydes. The high yielding transformation is
Optical enrichment in enzyme-catalyzed resolution of 1-aryl-2,2-dimethyl-1,3-propanediols
Mukherjee, Chandrani,Mohapatra, Prabhu P.,Youssef, Dani,Jha, Amitabh
, p. 1 - 6 (2017/01/10)
Novozym 435 efficiently catalyzed the chemo-, regio-, and enantioselective transesterification of 1-aryl-2,2-dimethyl-1,3-propanediols in different organic solvents with vinyl acetate as the acetyl donor at room temperature. This enzyme-catalyzed chemical
Novel enantioselective direct aldol-type reaction promoted by a chiral phosphine oxide as an organocatalyst
Kotani, Shunsuke,Shimoda, Yasushi,Sugiura, Masaharu,Nakajima, Makoto
supporting information; experimental part, p. 4602 - 4605 (2009/10/26)
Chiral phosphine oxide successfully catalyzed the direct aldol-type reactions of cyclohexanone derivatives and benzaldehyde derivatives in high stereoselectivities. The reaction mechanism involves the in situ formation of trichlorosilyl enol ethers. The present reaction could be extended to the cross-aldol reactions between two aldehydes.
