118263-97-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
1-Methyl-2,4-piperidinedione is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new and effective drugs and pesticides.
Used in Organic Synthesis:
1-Methyl-2,4-piperidinedione is used as a reagent in organic synthesis, particularly for the formation of cyclic amides and lactams, which are important intermediates in the production of various organic compounds.
Used in Specialty Chemical Production:
1-Methyl-2,4-piperidinedione is utilized as a precursor in the production of specialty chemicals, enabling the creation of unique and high-value chemical products.
Used in Polymer Manufacturing:
1-Methyl-2,4-piperidinedione is used as a stabilizer in the manufacturing of polymers, improving the stability and performance of the final polymer products.

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 79-04-9 chloroacetyl chloride 
• 851726-48-2 ethyl 3-((3-ethoxy-3-oxopropyl)(methyl)amino)-3-oxopropanoate 
• 93758-45-3 Methyl 1-methyl-2,4-dioxopiperidine-3-carboxylate 

Downstream Products

• 19686-05-6 2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 1426943-76-1 1-methyl-4-(p-tolylamino)-5,6-dihydropyridin-2(1H)-one 

Relevant academic research and scientific papers

One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement

The efficient generation of novel, N-linked benzamidines resulting from a regiospecific rearrangement of quinazolinones is described. This methodology study explored reaction parameters including the effect of changing solvent and temperature, as well as varying electronic substituents on the structural core. The transformation was extensively optimized in terms of reaction conditions and scope, resulting in a protocol that consistently affords diversely functionalized amidines in high yield. The process permits regional structural derivatization that was previously inaccessible, and the multistep process was also reduced to a telescoped, five-step sequence that efficiently affords pharmacologically unique (E)-benzamidoamidines from N-BOC protected γ- and δ-amino acids.

SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY

This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

New CRTH2 Antagonists

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.