1184-65-2Relevant articles and documents
Synthesis and synergetic anti-tumor activity evaluation of dihydroartemisinin-organogermanium(IV) compound
Lu, Peng,Yao, Shuguang,Cai, Jiye,Yang, Pei-Hui
, p. 5294 - 5297 (2014)
Dihydroartemisinin (DHA), a semi-synthetic derivative of the herb artemisinin, has shown commendable bioactivity. In this paper, a novel dihydroartemisinin-organogermanium (DHA-Ge) compound was synthesized, characterized and its potential anti-tumor activity was evaluated by various methods. MTT results demonstrated that DHA-Ge could effectively inhibit the proliferation of HepG2 cells and showed their dose-dependent properties. The IC50 value of inhibition effect on HepG2 cells of DHA-Ge was 10.23 μg/ml which was lower than 39.44 μg/ml of DHA. Flow cytometric results suggested that DHA-Ge could induce apoptosis of HepG2 cells and the apoptosis rate was 20.26% after 24 h treatment with 56.8 μg/ml DHA-Ge concentration. Atomic force microscopy images showed that HepG2 cells were collapsed and the cell nucleus were fragmented after 24 h treatment. All these results together showed that the DHA-Ge possessed desirable synergetic enhanced anti-tumor effects and could be developed as a suitable tumor therapeutic agent.
In situ Ge-Ge bond formation under ambient conditions: Synthesis, characterization and reactivity of organo-functionalized telluridogermanate complexes
Heimann, Samuel,Holynska, Malgorzata,Dehnen, Stefanie
, p. 1881 - 1883 (2011)
Unprecedented noradamantane-type compounds [(R2,3Ge) 4Te5] (R2 = CH2CH2COOH, R3 = CH(CH2COOH)2), containing a Ge-Ge bond, yield from reactions of R2,3GeCl3 with Na2Te or Li2Te in THF, while reactions with R1GeCl3 (R1 = CMe2CH2COMe) afford a double-decker-type cage [(R3Ge)4Te6]; by reaction with hydrazine, the latter reacts to the hydrazone functionalized, monomeric anion [(R 4Ge)Te2]- (R4 = CMe 2CH2CNNH2Me).
Stabilization of the first selenogermylene as the monomeric pentacarbonyltungsten(0) complex
Du Mont, Wolf-W.,Lange, Lutz,Pohl, Siegfried,Saak, Wolfgang
, p. 1395 - 1399 (2008/10/08)
Bis[(2,4,6-tri-tert-butylphenyl)seleno]germylene, formed in situ by reaction of lithium 2,4,6-tri-tert-butylphenyl selenide with the germanium dichloride dioxane complex, was trapped as the monomeric pentacarbonyl[bis((2,4,6-tri-tert-butylphenyl)seleno)germylene]tungsten(0) complex. Reaction of bis-(2,4,6-tri-tert-butylphenyl) diselenide with the germanium dichloride dioxane complex provides dichlorobis((2,4,6-tri-tert-butylphenyl)seleno)germane. This tetravalent germanium compound and bis-(2,4,6-tri-tert-butylphenyl) diselenide were identified as byproducts when preparation and isolation of the monomeric selenogermylene was attempted. The structure of the selenogermylene tungsten(0) complex was determined from single-crystal X-ray diffraction data. The complex crystallizes (with one toluene per molecule) in the monoclinic space group P21/c with a = 1077.4 (2), b = 1667.2 (2), c = 2880.9 (2) pm, β = 98.33°, and Z = 4. The molecule contains trigonal planar germanium with bonds to tungsten and to two nonequivalent selenium atoms (Ge-Se, 231.4 (2) and 234.6 (2) pm; Ge-W, 252.8 (1) pm). Well-resolved 1H, 13C, and 77Se NMR signals for the two (2,4,6-tri-tert-butylphenyl)seleno groups of the selenogermylene complex indicate hindered rotation around the Ge-Se bonds at room temperature in solution.
