1185-34-8Relevant articles and documents
Short eight-steps total synthesis of racemic asteriscunolide C
Fernandes, Rodney A.,Chavan, Vijay P.,Panja, Arpita
, p. 2103 - 2108 (2017)
A concise total synthesis of racemic asteriscunolide C in eight steps has been described starting from neopentane diol involving an efficient Yamaguchi esterification using an aldehyde-acid, intramolecular Horner–Wittig–Emmons olefination, and a late stage ring-closing metathesis to construct the strained 11-membered ring with one Z- and two E-double bonds.
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Yanovskaya,L.A. et al.
, (1962)
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Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties
Ding, Hueisch-Jy,Huang, Ying-Fong,Tzeng, Cherng-Chyi,Wei, Li-Mei,Yeh, Si-Jung
, p. 3199 - 3202 (1999)
Tc-D,D- and Tc-L,L-HMPAO were synthesized. The stability of Tc-D,D- and Tc-L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotometric and three strips methods. Cerebral uptake (%D in brain) for the L,L-isomer is higher than the D,D- and d,l-isomer in rats. Delayed studies shows that Tc-L,L-HMPAO reveals less washout and reflects a higher cerebral deposition properties than the D,D- and d,l-isomer.
Development of chiral bis-hydrazone ligands for the enantioselective cross-coupling reactions of aryldimethylsilanolates
Denmark, Scott E.,Chang, Wen-Tau T.,Houk,Liu, Peng
supporting information, p. 313 - 366 (2016/09/09)
A palladium-catalyzed, enantioselective, aryl-aryl cross-coupling reaction using 1-naphthyldimethylsilanolates and chiral bis-hydrazone ligands has been developed. A family of glyoxal bis-hydrazone ligands containing various 2,5-diarylpyrrolidine groups was prepared to evaluate the influence of ligand structure on the rate and enantioselectivity of the cross-coupling. New synthetic routes to the 1-amino-2,5-diarylpyrrolidines were developed to enable the structure/reactivity-selectivity studies. Role reversal experiments of aryldimethylsilanolates and aryl bromides result in biaryl products with the same configuration and similar enantioselectivities implying that reductive elimination is the stereodetermining step. The origin of stereoselectivity is rationalized through computational modeling of diarylpalldium(II) complex which occurs through a conrotatory motion for the two aryl groups undergoing C-C bond formation.