Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties

Article abstract of DOI:10.1016/S0960-894X(99)00557-0

Tc-D,D- and Tc-L,L-HMPAO were synthesized. The stability of Tc-D,D- and Tc-L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotometric and three strips methods. Cerebral uptake (%D in brain) for the L,L-isomer is higher than the D,D- and d,l-isomer in rats. Delayed studies shows that Tc-L,L-HMPAO reveals less washout and reflects a higher cerebral deposition properties than the D,D- and d,l-isomer.