118511-81-2Relevant articles and documents
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs
Yang, Shyh-Ming,Tang, Yuting,Rano, Thomas,Lu, Huajun,Kuo, Gee-Hong,Gaul, Michael D.,Li, Yaxin,Ho, George,Lang, Wensheng,Conway, James G.,Liang, Yin,Lenhard, James M.,Demarest, Keith T.,Murray, William V.
, p. 1437 - 1441 (2014/03/21)
Design, synthesis, and biological evaluation of pyridazine-based, 4-bicyclic heteroaryl-piperidine derivatives as potent stearoyl-CoA desaturase-1 (SCD1) inhibitors are described. In a chronic study of selected analog (3e) in Zucker fa/fa (ZF) rat, dose-dependent decrease of body weight gain and plasma fatty acid desaturation index (DI) in both C16 and C18 are also demonstrated. The results indicate that the plasma fatty acid DI may serve as an indicator for direct target engagement and biomarker for SCD1 inhibition.
Dipeptides which promote release of growth hormone
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, (2008/06/13)
Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis. STR1
SIMPLE SYNTHESIS OF 1-(AZACYCLOALKYL)INDOLES USING EXCLUSIVE ORTHO α-CHLOROACETYLATION OF N-(AZACYCLOALKYL)ANILINES
Sasakura, Kazuyuki,Adachi, Makoto,Sugasawa, Tsutomu
, p. 265 - 274 (2007/10/02)
Use of 2-(azacycloalkyl)amino-α-chloroacetophenones (4) as starting material makes possible simple synthesis of 1-(azacycloalkyl)indoles (2).