32989-69-8

Usage

Molecular weight

229.28 g/mol

Chemical class

Pyrrolidine derivative

Functional groups

Nitro group (-NO2) and phenyl group (C6H5)

Nitroalkene derivative

Yes

Potential applications

Pharmaceutical and industrial applications

Presence of nitrophenyl group

Yes, which makes it potentially useful for the synthesis of various biologically active compounds

Safety concerns

Potential health hazards if not properly managed and used in a controlled environment

Stereochemistry

(E)-2-(2-nitrophenyl)ethenyl group, indicating the presence of a double bond with trans configuration

Solubility

Not mentioned in the material provided, but generally, pyrrolidine derivatives are soluble in organic solvents like ethanol, methanol, and dichloromethane

Stability

Not mentioned in the material provided, but generally, nitro compounds can be sensitive to heat and light, so it is advisable to store in a cool, dark place and handle with care

Reactivity

Not mentioned in the material provided, but nitro compounds can be reactive, especially with reducing agents and nucleophiles, so proper precautions should be taken during synthesis and handling

Purity

Not mentioned in the material provided, but the purity of the compound should be confirmed through analytical techniques like NMR, HPLC, or mass spectrometry before use in any application

Structural features

The compound consists of a pyrrolidine ring fused to an ethenyl group, which is connected to a 2-nitrophenyl group through a carbon-carbon double bond

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 5564-73-8 1-(dimethoxymethyl)pyrrolidine 
• 123-75-1 pyrrolidine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 79844-33-0 2-(2-nitrophenyl)acetaldehyde dimethyl acetal 
• 120-72-9 indole 
• 592478-96-1 N-[2-(2,2-dimethoxyethyl)phenyl]formamide 
• 592479-02-2 2-(2-isocyanophenyl)acetaldehyde dimethyl acetal 
• 150760-45-5 2-(2,2-dimethoxyethyl)-benzeneamine 
• 951024-75-2 C₂₇H₂₈N₂O₇ 
• 951024-80-9 C₂₉H₃₆N₂O₉ 
• 951024-79-6 C₂₅H₃₂N₂O₇ 
• 951024-74-1 C₂₈H₃₆N₂O₇ 
• 951024-68-3 C₂₂H₂₂N₂O₃ 
• 951024-67-2 C₂₄H₃₀N₂O₅ 
• 604009-20-3 [1-(1-benzyl-piperidin-4-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 616898-64-7 oxo-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 616898-63-6 [1-(1-benzyl-pyrrolidin-3-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 

Relevant academic research and scientific papers

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.

Application of the Cleavable Isocyanide in Efficient Approach to Pyroglutamic Acid Analogues with Potential Biological Activity

Two efficient procedures have been developed for the synthesis of pyroglutamic acid analogues 28, 29, and 34. According to the first method the Ugi (4C3C) reaction is followed by a post-transformation reaction, and the second method involves the Michael a

New entry to convertible isocyanides for the Ugi reaction and its application to the stereocontrolled formal total synthesis of the proteasome inhibitor omuralide

The development of a new convertible isocyanide, indole-isocyanide, for ready access to pyroglutamic acids culminated in the formal total synthesis of the proteasome inhibitor omuralide featuring a stereocontrolled Ugi reaction. Indole-isocyanide was name

Development of a manufacturing process for 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole: A key intermediate for protein kinase C inhibitor LY317615

This contribution describes process development leading to the production of 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole (11). The title compound 11 was produced via a Leimgruber-Batcho indole synthesis using key intermediates 2-(2,2-dimethoxyethyl

Strategies for the synthesis of N-(azacycloalkyl)bisindolylmaleimides: Selective inhibitors of PKCβ

N-(Azacycloalkyl)bisindolylmaleimides 1 have been identified to be selective inhibitors of PKCβ. This manuscript will describe the synthetic approaches employed to prepare this class of compounds that resulted in development of efficient methods for prepa

Intermediates for indoles

Ortho-nitrotoluenes are condensed with formamide acetals to yield the corresponding otho-nitro-β-aminestyrenes which undergo cyclization upon reduction to yield indoles.