79844-33-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,2-Dimethoxyethyl)-2-nitrobenzene is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new medications and improve existing ones.
Used in Dye Industry:
In the dye industry, 1-(2,2-Dimethoxyethyl)-2-nitrobenzene is used as a chemical intermediate to produce various dyes, contributing to the coloration and quality of products.
Used in Organic Chemicals Production:
1-(2,2-Dimethoxyethyl)-2-nitrobenzene is also utilized in the production of other organic chemicals, where it serves as a versatile building block for creating a range of different chemical products.
Used in Medical Research:
Due to its anesthetic properties, 1-(2,2-Dimethoxyethyl)-2-nitrobenzene is used in medical research for the development and study of anesthetic agents and their applications in medicine.
It is crucial to handle 1-(2,2-Dimethoxyethyl)-2-nitrobenzene with care, as it is toxic and can cause skin and eye irritation upon contact, necessitating proper safety measures during its use and manipulation.

Upstream product

• 624-91-9 methyl nitrite 
• 579-71-5 2-nitrostyrene 
• 79844-32-9 2-nitro-β-acetoxystyrene 
• 67-56-1 methanol 
• 20973-67-5 N,N-dimethyl-2-(2-nitrophenyl)ethenylamine 
• 1969-73-9 (2-nitrophenyl)acetaldehyde 
• 75-18-3 dimethylsulfide 
• 88-72-2 1-methyl-2-nitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 32989-69-8 trans-2-nitro-β-pyrrolidinostyrene 
• 75867-47-9 trimethyl((2-nitrophenyl)ethynyl)silane 
• 3289-82-5 1-hydroxyindole 
• 32991-03-0 trans-β-dimethylamino-2-nitrostyrene 
• 119-66-4 2-nitrobenzenediazonium chloride 

Downstream Products

• 201486-48-8 N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide 
• 201486-49-9 N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-2,4-dimethoxy-benzamide 
• 201486-60-4 1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-ol 
• 201486-52-4 1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-one 
• 201486-50-2 (E)-N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-3-phenyl-acrylamide 
• 201486-51-3 Furan-2-carboxylic acid [2-(2,2-dimethoxy-ethyl)-phenyl]-amide 
• 201486-54-6 (2,4-Dimethoxy-phenyl)-indol-1-yl-methanone 
• 201486-62-6 1-Indol-1-yl-5-phenyl-pentan-1-ol 
• 201486-53-5 1-Indol-1-yl-5-phenyl-pentan-1-one 
• 201486-55-7 (E)-1-(1H-indol-1-yl)-3-phenylprop-2-en-1-one 
• 604009-20-3 [1-(1-benzyl-piperidin-4-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 616898-64-7 oxo-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 616898-63-6 [1-(1-benzyl-pyrrolidin-3-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 170364-57-5 enzastaurin 

Relevant academic research and scientific papers

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.

TFA-catalysed tandem double cyclisation: A one-pot, metal-free routes for novel indolo-imidazo[1,2-a]pyridine derivatives

A transition-metal free, one-pot tandem synthetic routes for novel indole and imidazo[1,2-a]pyridine derivative hybrids have been established. An efficient three-component reaction was designed with incorporation of two sequential Groebke–Blackburn–Bienay

Application of the Cleavable Isocyanide in Efficient Approach to Pyroglutamic Acid Analogues with Potential Biological Activity

Two efficient procedures have been developed for the synthesis of pyroglutamic acid analogues 28, 29, and 34. According to the first method the Ugi (4C3C) reaction is followed by a post-transformation reaction, and the second method involves the Michael a

New entry to convertible isocyanides for the Ugi reaction and its application to the stereocontrolled formal total synthesis of the proteasome inhibitor omuralide

The development of a new convertible isocyanide, indole-isocyanide, for ready access to pyroglutamic acids culminated in the formal total synthesis of the proteasome inhibitor omuralide featuring a stereocontrolled Ugi reaction. Indole-isocyanide was name

Development of a manufacturing process for 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole: A key intermediate for protein kinase C inhibitor LY317615

This contribution describes process development leading to the production of 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole (11). The title compound 11 was produced via a Leimgruber-Batcho indole synthesis using key intermediates 2-(2,2-dimethoxyethyl

Microwave-assisted in situ deprotection and ω-methoxylation of TMS-protected aryl alkynes

Using microwave technology, rapid ω-methoxylation of aryl alkynes is possible.

Strategies for the synthesis of N-(azacycloalkyl)bisindolylmaleimides: Selective inhibitors of PKCβ

N-(Azacycloalkyl)bisindolylmaleimides 1 have been identified to be selective inhibitors of PKCβ. This manuscript will describe the synthetic approaches employed to prepare this class of compounds that resulted in development of efficient methods for prepa

Synthesis of 3-methoxyquinolines via cyclization of 1-isocyano-2-(2-lithio-2-methoxyethenyl)benzenes

2-(2-Isocyanophenyl)acetaldehyde dimethyl acetals were treated with excess LDA to generate 1-isocyano-2-(2-lithio-2-methoxyethenyl)benzenes, which cyclized intramolecularly to afford 3-methoxyquinolines in good to excellent yields.

2-(2-aminophenyl)-acetaldehyde dimethyl acetal: A novel reagent for the protection of carboxylic acids

The synthesis and use of 2-(2-aminophenyl)-acetaldehyde dimethyl acetal 1 are described. The amides 2, derived from this amine and carboxylic acids, are stable under basic conditions and thus can be regarded as the protected carboxylic acids. The corresponding carboxylic acids are regenerated by conversion of 2 into indolylamides 3 by treatment with CSA and subsequent hydrolysis with LiOOH or NaOH. In addition, 3 can be easily converted to esters, amides, and aldehydes.

Palladium-Catalyzed Synthesis of Indoles from 2-Nitrostyrenes

In the presence of palladium salts, oxidation of 2-nitrostyrenes 1 with nitrous acid alkyl esters 2 resulted in the formation of 2-nitrophenylacetaldehyde dialkyl acetals 3.Reductive cyclization of the acetals 3 with iron powder in acetic acid afforded indoles 5 in good yield.