118527-01-8Relevant academic research and scientific papers
Enantioselective total synthesis of (+)-cassiol
Petrova, Krastina V.,Mohr, Justin T.,Stoltz, Brian M.
supporting information; experimental part, p. 293 - 295 (2009/08/08)
(Chemical Equation Presented) An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd2(pmdba) 3 and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps.
Comparison of vinyl organolithium and organopalladium reagents for intramolecular conjugate addition to vinyl sulfones
Lee,Fuchs
, p. 5209 - 5212 (2007/10/02)
Synthesis of cis-fused bicyclic ethers (5-10) by intramolecular conjugate addition of vinyl lithium and organopalladium reagents to cyclohexenyl/pentenyl moiety of vinyl sulfones is described.
Controlled endocyclic and exocyclic-γ-metalations of β-substituted cyclohexenyl sulfones. Regiospecific syntehses of γ-oxygenated cyclohexenyl sulfones.
lee,Fuchs
, p. 2861 - 2864 (2007/10/02)
β-Substituted cyclohexenyl sulfones may be regiospecifically isomerized to either endocyclic or exocyclic allyl sulfones. Epoxidation of these materials followed by a second metalation yields γ-hydroxy cyclohexenyl sulfones 6 and 7. Subjection of either o
