118638-76-9

Upstream product

• 622-08-2 2-Benzyloxyethanol 
• 10378-06-0 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)[1,2-d]-2-oxazoline 
• 3006-60-8 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranose 
• 3006-60-8 2-acetamido-3,4,6-tri-O-acetyl-D-glucopyranosyl acetate 
• 7512-17-6 N-Acetyl-D-glucosamine 
• 100-39-0 benzyl bromide 
• 108-24-7 acetic anhydride 
• 1261030-95-8 1-O-(2-benzyloxyethyl)-2-deoxy-2-phthalimino-3,4,6-tri-O-acetyl-β-D-glucopyranoside 
• 63000-69-1 1-bromo-2-deoxy-2-N-phthalimido-3,4,6-tri-O-acetyl-β-D-glucopyranose 

Downstream Products

• 132928-84-8 Tetradecanoic acid (4aR,6R,7R,8R,8aS)-6-[2-(diphenoxy-phosphoryloxy)-ethoxy]-2,2-dimethyl-7-tetradecanoylamino-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 118638-82-7 2-(diphenylphosphonooxy)ethyl 2-deoxy-3-O-tetradecanoyl-2-tetradecanoylamino-β-D-glucopyranoside 
• 118638-80-5 2-benzyloxyethyl 2-deoxy-4,6-O-isopropylidene-3-O-tetradecanoyl-2-tetradecanoylamino-β-D-glucopyranoside 
• 118638-77-0 2-benzyloxyethyl 3,4,6-tri-O-acetyl-2-deoxy-2-tetradecanoylamino-β-D-glucopyranoside 
• 118638-79-2 2-benzyloxyethyl 2-deoxy-4,6-O-isopropylidene-2-tetradecanoylamino-β-D-glucopyranoside 
• 118638-78-1 2-benzyloxyethyl 2-deoxy-2-tetradecanoylamino-β-D-glucopyranoside 
• 132928-83-7 Acetic acid (2R,3S,4R,5R,6R)-4-acetoxy-2-acetoxymethyl-5-amino-6-(2-benzyloxy-ethoxy)-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Chemo-enzymatic synthesis of glycosylated insulin using a GlcNAc tag

Artificial insulin with an N-linked oligosaccharide was synthesized by a chemo-enzymatic method using endo-β-N-acetylglucosaminidase from Mucor hiemalis (Endo-M). GlcNAc-modified insulin was prepared by the reaction of the carboxymethyl glycoside of GlcNA

ENDOSOMAL CLEAVABLE LINKERS

The present disclosure relates generally to cleavable linkers and uses thereof.

SILICON PARTICLES TARGETING TUMOR CELLS

A silicon particle comprising a silicon body, a functionalized silica surface surrounding the silicon body, and a targeting moiety specifically targeting tumor cells, and, optionally, an enzymatically metabolizable compound,is useful in the treatment of cancer by producing cell death after particle internalization.

Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water

Carbohydrate-aromatic interactions are highly relevant for many biological processes. Nevertheless, experimental data in aqueous solution relating structure and energetics for sugar-arene stacking interactions are very scarce. Here, we evaluate how structural variations in a monosaccharide including carboxyl, N-acetyl, fluorine, and methyl groups affect stacking interactions with aromatic DNA bases. We find small differences on stacking interaction among the natural carbohydrates examined. The presence of fluorine atoms within the pyranose ring slightly increases the interaction with the C-G DNA base pair. Carbohydrate hydrophobicity is the most determinant factor. However, gradual increase in hydrophobicity of the carbohydrate does not translate directly into a steady growth in stacking interaction. The energetics correlates better with the amount of apolar surface buried upon sugar stacking on top of the aromatic DNA base pair.