118642-72-1Relevant articles and documents
Studies on New Acidic Azoles as Glucose-Lowering Agents in Obese, Diabetic db/db Mice
Kees, Kenneth L.,Caggiano, Thomas J.,Steiner, Kurt E.,Fitzgerald, John J.,Kates, Michael J.,et al.
, p. 617 - 628 (1995)
Bioisosteric substitution was used as a tool to generate several new structural alternatives to the thiazolidine-2,4-dione and tetrazole heterocycles as potential antidiabetic agents.Among the initial leads that emerged from this strategy, a family of aci
Deacylative oxidation strategy for the preparation of α- functionalized carbonyls
Brodsky, Benjamin H.,Du Bois
, p. 2619 - 2621 (2007/10/03)
(Matrix Presented) α-Alkoxylation and amination of carbonyl derivatives is made possible through a unique deacylative coupling reaction that proceeds via in situ Rh-carbene formation and subsequent heteroatom-H (X-H) insertion. Reactions perform optimally
ALKYLATION DU TRIFLUOROACETYLACETATE D'ETHYLE METHODE GENERALE D'ACCES AUX TRIFLUOROMETHYLCETONES. 2eme PARTIE: ALKYLATIONS INDIRECTS DU TFAAE
Aubert, Corinne,Begue, Jean-Pierre,Charpentier-Morize, Micheline,Nee, Gerard,Langlois, Bernard
, p. 377 - 394 (2007/10/02)
A versatile method of alkylation of ethyltrifluoroacetylacetate (ETFAA) allowed selective C-alkylation of ETFAA, whatever the structure of alkyl halide was, providing that the carbonyl function was masked into a dioxolan 3 or a N,N-dimethyl hydrazone 5.These last derivatives were easily alkylated and their specific deprotection led to various C-alkylated ETFAA which in turn allowed, by a simple decarbethoxylation, the preparation of the corresponding trifluoromethyl ketones in good yields.