118666-03-8Relevant academic research and scientific papers
Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors
Bass, Amr K.A.,Nageeb, El-Shimaa M.,El-Zoghbi, Mona S.,Mohamed, Mamdouh F.A.,Badr, Mohamed,Abuo-Rahma, Gamal El-Din A.
, (2021/12/27)
Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-cyanopyridines as a novel cap moiety linked with aliphatic /aromatic linker bearing carboxylic acid 3a-g, hydroxamic acid 4a-g or 2-aminoanilide moieties 5a-g as z
Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches
Boraei, Ahmed T.A.,Eltamany, Elsayed H.,Ali, Ibrahim A.I.,Gebriel, Sara M.,Nafie, Mohamed S.
, (2021/04/27)
Liver cancer is the most common type of cancer in many countries. New studies and statistics show rising liver cancer worldwide, so it is essential to seek new agents for this type of cancer. PIM1 has an attractive target in the discovery of cancer medica
Efficient Approach to the Synthesis of Ethyl 3-Amino-4,6-diarylfuro[2,3-b] pyridine-2-carboxylate
Shah, Hetal C.,Shah, Vaishali H.,Desai, Nirmal D.
experimental part, p. 3126 - 3140 (2009/12/01)
Novel ethyl 3-amino-4,6-diarylfuro[2,3-b]pyridine-2-carboxylate were synthesized by Thorpe-Ziegler cyclization using solid-liquid phase-transfer catalysis conditions.
Synthesis of furo[2,3-b]pyridine amidines with antianaphylatic activity
Wagner,Prantz
, p. 250 - 253 (2007/10/02)
The synthesis of furo[2,3-b]pyridine formamidines (D/1-D/11, F) was realized by the reaction of the 3-amino-furo[2,3-b]pyridines C/1-C/11 and E, substituted in position 2 with a carbonyl moiety with dimethylformamide/phosphoroxide chloride or with N-formy
