1188-63-2

Usage

Uses

Used in Organic Synthesis:
4-Heptanone oxime is used as a reagent in chemical reactions for the synthesis of various organic compounds. Its unique properties make it a valuable component in creating a wide range of chemical products.
Used in Pharmaceutical Production:
As an intermediate in the production of pharmaceuticals, 4-heptanone oxime plays a crucial role in the development of new drugs and medicines. Its involvement in the synthesis process is essential for creating effective and safe pharmaceuticals.
Used in Inhibition of Advanced Glycation End Products:
4-Heptanone oxime is used as an inhibitor to prevent the formation of advanced glycation end products, which are associated with aging and various diseases. Its ability to inhibit these end products makes it a potential candidate for use in treatments targeting age-related conditions and diseases.
Used in Controlled Environments:
Due to its potential reactivity and toxicity, 4-heptanone oxime is typically handled and stored in a controlled environment. This ensures the safety of those working with the compound and minimizes the risk of adverse reactions or accidents.

InChI:InChI=1/C7H15NO/c1-3-5-7(8-9)6-4-2/h9H,3-6H2,1-2H3

Upstream product

• 123-19-3 4-heptanone 
• 682-29-1 4-chloro-4-nitrosoheptane 
• 97031-82-8 bis(4-nitrosoheptane) 
• 142-82-5 n-heptane 
• 64-17-5 ethanol 
• 60-29-7 diethyl ether 
• 7803-49-8 hydroxylamine 

Downstream Products

• 16751-59-0 4-heptylamine 
• 53442-84-5 C₁₆H₂₂ClNO₃ 
• 53443-47-3 C₁₅H₁₈Cl₃NO₃ 
• 53443-16-6 C₁₆H₂₁Cl₂NO₃ 
• 53442-95-8 C₁₇H₂₄ClNO₃ 
• 89796-76-9 4,4-dichloroheptane 
• 123-19-3 4-heptanone 
• 161837-48-5 O-cinnamyl 4-heptanone oxime 
• 5129-73-7 N-propylbutyrylamide 
• 150967-34-3 4-heptylideneaminoester of 4-(4,6-dimethoxypyrimidin-2-yloxy)-2-phenylfuran-3-carboxylic acid 
• 161330-97-8 O-((E)-3-Phenyl-allyl)-N-(1-propyl-butyl)-hydroxylamine 
• 71350-25-9 di-n-propyl ketone oxime O-allyl ether 
• 53443-34-8 C₁₅H₁₉Cl₂NO₃ 

Relevant academic research and scientific papers

Selective Production of Hydrazine by a Catalytic Oxidation Process over Ti-, V-, Ti-V- and Ti-B-Silicalites

A simple catalytic process to obtain hydrazine by oxidation of ketone-NH3 system by H2O2 is reported; Ti-, V-, Ti-V- and Ti-B-silicalites of MFI structure are found to be active as catalysts in this oxidation reaction.

Copper-catalyzed synthesis of thiazol-2-yl ethers from oxime acetates and xanthates under redox-neutral conditions

A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.

Novel cis- and trans-configured bis(oxime)platinum(II) complexes: Synthesis, characterization, and cytotoxic activity

Novel cis- and trans-configured bis(oxime)platinum(II) complexes have been synthesized and characterized by elemental analyses, IR, electrospray ionization mass spectrometry, multinuclear (1H, 13C, and 195Pt) NMR spectroscopy, and, in five cases, by X-ray diffraction. Their cytotoxicity was studied in the cisplatin-sensitive CH1 cell line as well as in inherently cisplatin-resistant SW480 cancer cells. Remarkably, every single dihalidobis(oxime)platinum(II) complex (with either a cis or trans configuration) shows a comparable cytotoxic potency in both cell lines, indicating a capacity of overcoming cisplatin resistance. Particularly strong cytotoxicities were observed in the case of trans-[PtCl2(R 2C=NOH)2] (R = Me, n-Pr, i-Pr) with IC50 values in the high nanomolar concentration range in both CH1 and SW480 cancer cells. These complexes are as potent as cisplatin in CH1 cells and up to 20 times more potent than cisplatin in SW480 cells. In comparison to transplatin, the novel compounds are up to 90 (CH1) and 120 times (SW480) more cytotoxic. The previously reported observation that the trans geometry yields a more active complex in the case of [PtCl2(Me2C=NOH)2] could be confirmed for at least two structural analogues.

A mild synthesis of vinyl halides and gem-dihalides using triphenyl phosphite-halogen-based reagents

A new application of (PhO)3P-halogen-based reagents to the synthesis of vinyl halides and gem-dihalides is described. Vinyl halides were prepared in good to excellent yields from enolizable ketones, whereas aldehydes afforded the corresponding gem-dihalides. The halogenation proceeded smoothly under mild conditions.