1188292-85-4Relevant academic research and scientific papers
Lewis Base/Copper Cooperatively Catalyzed Asymmetric α-Amination of Esters with Diaziridinone
Song, Jin,Zhang, Zi-Jing,Chen, Shu-Sen,Fan, Tao,Gong, Liu-Zhu
, p. 3177 - 3180 (2018)
An enantioselective α-amination of esters by a Lewis base/copper(I) cooperative catalysis strategy has been developed. The transient chiral C1-ammonium enolate generated from pentafluorophenyl ester and nucleophilic Lewis base is nicely compatible with the copper intermediate formed from N,N-di-t-butyldiaziridinone and Cu(I) to allow for high levels of stereochemical control. The cooperative catalytic reaction leads to a diverse set of highly enantioenriched hydantoins in good yields with excellent enantioselectivities (90-99% ee).
Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination of terminal olefin
Fu, Renzhong,Zhao, Baoguo,Shi, Yian
experimental part, p. 7577 - 7580 (2010/01/06)
(Chemical Equation Presented) This paper describes an asymmetric synthesis of the potent substance P receptor antagonist (+)-CP-99,994 from 4-phenyl-1-butene via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H diamination. 2009 American Chemical So
