Technology Process of methyl 3-((4S,5S)-1,3-di-tert-butyl-2-oxo-5-phenylimidazolidin-4-yl)propanoate
There total 10 articles about methyl 3-((4S,5S)-1,3-di-tert-butyl-2-oxo-5-phenylimidazolidin-4-yl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 2h;
DOI:10.1021/jo9015584
- Guidance literature:
-
With
dipyridinium dichromate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
DOI:10.1021/jacs.7b12628
- Guidance literature:
-
Multi-step reaction with 6 steps
1: copper(l) chloride; tributylphosphine; (-)-(S)-i-Pr-BTM / chloroform / 4 h / 70 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
3: boron trifluoride diethyl etherate / dichloromethane / 2.08 h / -78 °C
4: tetrahydrofuran / 12 h / 0 - 60 °C
5: sodium hydroxide; dihydrogen peroxide / water / 1 h / 20 °C
6: dipyridinium dichromate / N,N-dimethyl-formamide / 24 h / 20 °C
With
lithium aluminium tetrahydride; dipyridinium dichromate; tributylphosphine; (-)-(S)-i-Pr-BTM; boron trifluoride diethyl etherate; dihydrogen peroxide; copper(l) chloride; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jacs.7b12628
