118849-12-0Relevant articles and documents
A convenient synthesis of 5'-amino-5'-deoxythymidine and preparation of peptide-DNA hybrids
Tetzlaff, Charles N.,Schwope, Ina,Bleczinski, Colleen F.,Steinberg, Joshua A.,Richert, Clemens
, p. 4215 - 4218 (1998)
5'-Amino-5'-deoxythymidine was prepared from thymidine in two stops and converted to its known 5'-methoxytrityl-protected 3'-phosphoramidite building block for DNA assembly on solid supports. Using this building block, peptide- DNA hybrids were synthesize
Mercury-Free Automated Synthesis of Guanidinium Backbone Oligonucleotides
Skakuj, Kacper,Bujold, Katherine E.,Mirkin, Chad A.
, p. 20171 - 20176 (2019)
A new method for synthesizing deoxynucleic guanidine (DNG) oligonucleotides that uses iodine as a mild and inexpensive coupling reagent is reported. This method eliminates the need for the toxic mercury salts and pungent thiophenol historically used in me
Deoxynucleic Guanidines (DNG)- Modified Oligonucleotides and Methods of Synthesizing Deoxynucleic Guanidine Strands
-
, (2021/01/22)
Disclosed herein are spherical nucleic acids (SNAs) comprising oligonucleotides comprising one or more modified oligonucleotides, and methods of use thereof. Also disclosed are methods of synthesizing modified oligonucleotides for use in therapeutics, inc
LIPID FORMULATED SINGLE STRANDED RNA
-
Paragraph 0709; 0711, (2013/06/28)
The present invention provides compositions comprising a nucleic acid lipid particle and an oligomeric compound and uses thereof. In certain embodiments, such compositions are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.
Novel Dideoxynucleoside Derivatives
-
Page/Page column 10; 11, (2008/06/13)
The present invention discloses a 5′-amino-2′-fluoro-2′,5′-dideoxynucleoside derivative represented by the following formula [1]: (wherein R1 represents a nucleic acid base which may have a protecting group; R2 represents a hydrogen atom or a protecting group of an amino group; R3 represents a hydrogen atom or a protecting group of a hydroxyl group); a dideoxynucleoside-insoluble carrier bound substance prepared by binding said dideoxynucleoside derivative to an insoluble carrier, and an oligonucleotide analogue into which said dideoxynucleoside derivative is introduced. The oligonucleotide analogue being introduced with a dideoxynucleoside derivative of the present invention has excellent thermal stability and also high binding affinity when duplex is formed. Also, it is anticipated that it has high resistance to nucleases. Further, the dideoxynucleoside derivative of the present invention can be used as an amidite reagent to be used for nucleic acid synthesis, and also as a starting material for solid phase synthesis of nucleic acid by binding the amidite reagent to a solid phase.
COMPOSITIONS AND METHODS USING AMINOGLYCOSIDES TO BIND DNA AND RNA
-
Page/Page column 9; 112; sheet 51, (2008/06/13)
Disclosed are compositions and methods related to aminoglycoside dimers aminoglycoside conjugates, and their uses.
Synthesis of neomycin-DNA/peptide nucleic acid conjugates
Charles,Arya, Dev P.
, p. 145 - 160 (2007/10/03)
Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isoth
Synthesis of aminoglycoside-DNA conjugates
Charles,Xue, Liang,Arya, Dev P.
, p. 1259 - 1262 (2007/10/03)
Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.
Solid-Phase Synthesis of Oligodeoxynucleotides Containing Phosphoramidate Internucleotide Linkages and their Specific Chemical Cleavage
Bannwarth, Willi
, p. 1517 - 1527 (2007/10/02)
Oligonucleotides bearing phosphoramidate internucleotide linkages can be prepared chemically by standard solid-phase DNA synthesis.Thus, phosphoramidate internucleotide bonds can be placed at will into specific positions within a given DNA fragment.The ba