118908-18-2

Upstream product

• 540-63-6 ethane-1,2-dithiol 
• 118908-17-1 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-(5-methoxycarbonyl-3-oxo-pentyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 38754-71-1 (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate 
• 118908-16-0 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-5-methoxycarbonyl-3-oxo-pent-1-enyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 31752-99-5 (-)-Corey lactone 5-(4-phenylbenzoate) 

Downstream Products

• 133161-96-3 (Z)-9α-11β-dihydroxy-15-oxo-2,3,18.19-tetranorprost-5-ene-1,20-dioic acid 
• 34069-64-2 6-[(1R,2R,3S,5S)-2-((E)-4-Carboxy-but-2-enyl)-3,5-dihydroxy-cyclopentyl]-4-oxo-hexanoic acid 

Relevant academic research and scientific papers

SYNTHESIS OF THE MAJOR URINARY METABOLITE OF PROSTAGLANDIN D2

Starting from the Corey lactone (3), the total synhesis of a specific urinary metabolite of prostaglandin D2, viz., (Z)-9α,11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid (1) and its 5E-isomer is described.The synthetic mater