1189586-14-8

Basic information

• Product Name: DDE-L-LYS(BOC)-OH
• Synonyms: DDE-L-LYS(BOC)-OH;DDE-LYS(BOC)-OH;N-ALPHA-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)ETHYL-N-EPSILON-BOC-L-LYSINE;N-ALPHA-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)ETHYL-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE;N-ALPHA-(4-4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)ETHYL-N-EPSILON-TERT-BUTYLOXYCARBONYL-L-LYSINE
• CAS NO: 1189586-14-8
• Molecular Formula: C₂₁H₃₄N₂O₆
• Molecular Weight: 410.5
• Mol File: 1189586-14-8.mol

Chemical Properties

• Boiling Point: 591.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.137±0.06 g/cm3(Predicted)
• PKA: 12.92±0.46(Predicted)
• CAS DataBase Reference: DDE-L-LYS(BOC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: DDE-L-LYS(BOC)-OH(1189586-14-8)
• EPA Substance Registry System: DDE-L-LYS(BOC)-OH(1189586-14-8)

Safety Data

• Hazardous Substances Data: 1189586-14-8(Hazardous Substances Data)

Upstream product

• 126-81-8 dimedone 
• 1755-15-3 2-acetyldimedone 
• 2418-95-3 (S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid 
• 94142-97-9 2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione 

Downstream Products

• 1131915-61-1 Dde-Lys(Boc)-OAll 

Relevant articles and documents

ONE-BEAD-TWO-COMPOUND MACROCYCLIC LIBRARY AND METHODS OF PREPARATION AND USE

A one-bead-two-compound combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions with use as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and libraries of macrocyclic compounds are useful as research tools in drug discovery and/or to treat or prevent a range of diseases or disorders.

One-Bead-Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2

Identification of molecular ligands that recognize peptides or proteins is significant but poses a fundamental challenge in chemical biology and biomedical sciences. Development of cyclic peptidomimetic library is scarce, and thus discovery of cyclic peptidomimetic ligands for protein targets is rare. Herein we report the unprecedented one-bead-two-compound (OBTC) combinatorial library based on a novel class of the macrocyclic peptidomimetics γ-AApeptides. In the library, we utilized the coding peptide tags synthesized with Dde-protected α-amino acids, which were orthogonal to solid phase synthesis of γ-AApeptides. Employing the thioether linkage, the desired macrocyclic γ-AApeptides were found to be effective for ligand identification. Screening the library against the receptor tyrosine kinase EphA2 led to the discovery of one lead compound that tightly bound to EphA2 (Kd = 81 nM) and potently antagonized EphA2-mediated signaling. This new approach of macrocyclic peptidomimetic library may lead to a novel platform for biomacromolecular surface recognition and function modulation.

Synthesis and applications of polyamine amino acid residues: Improving the bioactivity of an analgesic neuropeptide, neurotensin

Conjugated polyamines are potential carriers for biothera- peutics targeting the central nervous system. We describe an efficient synthesis of a polyamine-based amino acid, lysine-trimethylene(diNo-syl)-spermine(triBoc) with Dde or Fmoc orthogonal protect