118971-54-3

Basic information

• Product Name: (E)-4-(3-oxo-3-phenethoxyprop-1-enyl)-1,2-phenylene diacetate
• Synonyms: (E)-4-(3-oxo-3-phenethoxyprop-1-enyl)-1,2-phenylene diacetate
• CAS NO: 118971-54-3
• Molecular Weight: 368.386
• Mol File: 118971-54-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-4-(3-oxo-3-phenethoxyprop-1-enyl)-1,2-phenylene diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(3-oxo-3-phenethoxyprop-1-enyl)-1,2-phenylene diacetate(118971-54-3)
• EPA Substance Registry System: (E)-4-(3-oxo-3-phenethoxyprop-1-enyl)-1,2-phenylene diacetate(118971-54-3)

Safety Data

• Hazardous Substances Data: 118971-54-3(Hazardous Substances Data)

Upstream product

• 60-12-8 2-phenylethanol 
• 88623-81-8 3,4-diacetoxycinnamic acid 
• 331-39-5 caffeic acid 

Downstream Products

• 104594-70-9 Caffeic acid phenethyl ester 

Relevant articles and documents

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel

The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs. It has been reported that TREK-1 -/- mice were more sensitive than wild-type mice to painful stimuli, suggesting that activation of TREK-1 could result in pain inhibition. Here we report the synthesis of a series of substituted caffeate esters (12a-u) based on the hit compound CDC 2 (cinnamyl 3,4-dihydroxyl-α-cyanocinnamate). These analogs were evaluated for their ability to modulate TREK-1 channel by electrophysiology and for their in vivo antinociceptive activity (acetic acid induced-writhing assay) leading to the identification a series of novel molecules able to activate TREK-1 and displaying potent analgesic activity in vivo.