118995-17-8

Basic information

• Product Name: (2S,4R)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone
• Synonyms: (2S,4R)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone;(2S-trans)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone
• CAS NO: 118995-17-8
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 281.31
• Product Categories: Aromatics Compounds;Aromatics;Chiral Reagents;Heterocycles
• Mol File: 118995-17-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 157-159°C
• Boiling Point: 506.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.231±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, DMSO, Methanol
• PKA: -2.93±0.60(Predicted)
• CAS DataBase Reference: (2S,4R)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone(118995-17-8)
• EPA Substance Registry System: (2S,4R)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone(118995-17-8)

Safety Data

• Hazardous Substances Data: 118995-17-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 338-69-2 D-Alanine 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 1187832-16-1 (2S,4R)-4-(4-methoxybenzyl)-4-methyl-2-phenyl-3-(phenylcarbonyl)-1,3-oxazolidin-5-one 
• 1037074-43-3 (-)-(2S,4R)-3-benzoyl-4-benzyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one 
• 65-85-0 benzoic acid 
• 100-52-7 benzaldehyde 
• 118995-18-9 (2S,4R)-3-benzoyl-4-ethyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one 

Relevant articles and documents

KAPPA OPIOID RECEPTOR BINDING LIGANDS

Kappa opioid recep-tor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor, such as heroin or cocaine addictions.

Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3- hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3, 4-tetrahydro-3-isoquinolinecarboxamide (JDTic

In previous structure-activity relationship (SAR) studies, (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic, 3) was identified as the first pote