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119006-77-8

119006-77-8

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119006-77-8 Usage

Description

1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is a novel imidazole antifungal agent characterized by the presence of a 2,4'-difluorotrityl group attached to the nitrogen atom of the imidazole ring. 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is a white or almost white powder and is known for its potent broad-spectrum activity against various fungi, including dermatophytes, filamentous fungi, and yeasts.

Uses

Used in Antifungal Applications:
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is used as an antifungal agent for the treatment of mycosis of the skin. It exhibits excellent local and systemic tolerance in patients and is effective against both saprophytic and pathogenic fungi that affect animals and humans. The compound works by inhibiting fungal lanosterol 14α-demethylase, which is a crucial enzyme in the fungal cell membrane synthesis.
Used in Pharmaceutical Industry:
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is used as an active pharmaceutical ingredient in the development of antifungal medications. Its potent broad-spectrum activity and good tolerance make it a valuable compound for creating effective treatments for various fungal infections.
Used in Research and Development:
In the field of pharmaceutical research and development, 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole serves as a key compound for studying the structure-activity relationship of imidazole antifungal agents. This knowledge can be applied to design and synthesize new, more effective antifungal drugs with improved properties.
Brand Name:
The brand name for 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is Micetal, which is a topical antifungal agent used for the treatment of skin mycoses.

Originator

Uriach (Spain)

Check Digit Verification of cas no

The CAS Registry Mumber 119006-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,0,0 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 119006-77:
(8*1)+(7*1)+(6*9)+(5*0)+(4*0)+(3*6)+(2*7)+(1*7)=108
108 % 10 = 8
So 119006-77-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

119006-77-8 Well-known Company Product Price

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  • Sigma-Aldrich

  • (F0290000)  Flutrimazole  European Pharmacopoeia (EP) Reference Standard

  • 119006-77-8

  • F0290000

  • 1,880.19CNY

  • Detail

119006-77-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name flutrimazole

1.2 Other means of identification

Product number -
Other names Flutrimazolum [INN-Latin]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119006-77-8 SDS

119006-77-8Synthetic route

1H-imidazole
288-32-4

1H-imidazole

(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane
128092-75-1

(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
With triethylamine In acetonitrile for 3h; Heating; Yield given;
o-fluorobenzophenone
342-24-5

o-fluorobenzophenone

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h
2: thionyl chloride / 4 h / Heating
3: triethylamine / acetonitrile / 3 h / Heating
View Scheme
(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol
128092-72-8

(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 4 h / Heating
2: triethylamine / acetonitrile / 3 h / Heating
View Scheme
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

flutrimazole
119006-77-8

flutrimazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h
2: thionyl chloride / 4 h / Heating
3: triethylamine / acetonitrile / 3 h / Heating
View Scheme

119006-77-8Downstream Products

119006-77-8Relevant articles and documents

1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole useful as antifungal agent

-

, (2008/06/13)

The invention relates to 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole, useful as antifungal agent.

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole

-

, (2008/06/13)

-

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