119006-77-8 Usage
Description
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is a novel imidazole antifungal agent characterized by the presence of a 2,4'-difluorotrityl group attached to the nitrogen atom of the imidazole ring. 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is a white or almost white powder and is known for its potent broad-spectrum activity against various fungi, including dermatophytes, filamentous fungi, and yeasts.
Uses
Used in Antifungal Applications:
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is used as an antifungal agent for the treatment of mycosis of the skin. It exhibits excellent local and systemic tolerance in patients and is effective against both saprophytic and pathogenic fungi that affect animals and humans. The compound works by inhibiting fungal lanosterol 14α-demethylase, which is a crucial enzyme in the fungal cell membrane synthesis.
Used in Pharmaceutical Industry:
1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is used as an active pharmaceutical ingredient in the development of antifungal medications. Its potent broad-spectrum activity and good tolerance make it a valuable compound for creating effective treatments for various fungal infections.
Used in Research and Development:
In the field of pharmaceutical research and development, 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole serves as a key compound for studying the structure-activity relationship of imidazole antifungal agents. This knowledge can be applied to design and synthesize new, more effective antifungal drugs with improved properties.
Brand Name:
The brand name for 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole is Micetal, which is a topical antifungal agent used for the treatment of skin mycoses.
Originator
Uriach (Spain)
Check Digit Verification of cas no
The CAS Registry Mumber 119006-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,0,0 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 119006-77:
(8*1)+(7*1)+(6*9)+(5*0)+(4*0)+(3*6)+(2*7)+(1*7)=108
108 % 10 = 8
So 119006-77-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H
119006-77-8Relevant articles and documents
Synthesis and antifungal activity of a series of difluorotritylimidazoles
Bartroli,Alguero,Boncompte,Forn
, p. 832 - 835 (2007/10/02)
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) (15) was selected among a series of mono-, di- and trifluorotrityl-imidazole antifungal agents as the most potent fluorine containing analogue of clotrimazole.
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
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, (2008/06/13)
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