128092-75-1 Usage
Description
1-[Chloro(4-fluorophenyl)phenylmethyl]-2-fluorobenzene is a chemical compound with the molecular formula C21H16ClF2. It is a benzene derivative that features a chlorine atom, two fluorine atoms, and two phenyl groups. 1-[Chloro(4-fluorophenyl)phenylmethyl]-2-fluorobenzene is characterized by its unique structure and reactivity, making it a valuable building block in the synthesis of various pharmaceuticals, agrochemicals, and advanced materials.
Uses
Used in Pharmaceutical Industry:
1-[Chloro(4-fluorophenyl)phenylmethyl]-2-fluorobenzene is used as a key intermediate in the synthesis of new drugs. Its unique structure and reactivity contribute to the development of pharmaceuticals with novel therapeutic properties and improved efficacy.
Used in Agrochemical Industry:
In the agrochemical industry, 1-[Chloro(4-fluorophenyl)phenylmethyl]-2-fluorobenzene serves as a building block for the preparation of agrochemicals. Its incorporation into these products can enhance their effectiveness in pest control and crop protection.
Used in Advanced Materials:
1-[Chloro(4-fluorophenyl)phenylmethyl]-2-fluorobenzene is utilized in the development of advanced materials due to its unique structural and chemical properties. It can be incorporated into materials with specific applications, such as in electronics, coatings, or other high-performance materials.
Used in Research:
1-[Chloro(4-fluorophenyl)phenylmethyl]-2-fluorobenzene is also used in research settings as a model compound to study chemical reactions and explore new synthetic pathways. Its unique structure provides opportunities for understanding and optimizing various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 128092-75-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,0,9 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 128092-75:
(8*1)+(7*2)+(6*8)+(5*0)+(4*9)+(3*2)+(2*7)+(1*5)=131
131 % 10 = 1
So 128092-75-1 is a valid CAS Registry Number.
128092-75-1Relevant articles and documents
Novel inhibitors of the gardos channel for the treatment of sickle cell disease
McNaughton-Smith, Grant A.,Burns, J. Ford,Stocker, Jonathan W.,Rigdon, Gregory C.,Creech, Christopher,Arlington, Susan,Shelton, Tara,De Franceschi, Lucia
, p. 976 - 982 (2008/12/20)
Sickle cell disease (SCD) is a hereditary condition characterized by deformation of red blood cells (RBCs). This phenomenon is due to the presence of abnormal hemoglobin that polymerizes upon deoxygenation. This effect is exacerbated when dehydrated RBCs experience a loss of both water and potassium salts. One critical pathway for the regulation of potassium efflux from RBCs is the Gardos channel, a calcium-activated potassium channel. This paper describes the synthesis and biological evaluation of a series of potent inhibitors of the Gardos channel. The goal was to identify compounds that were potent and selective inhibitors of the channel but had improved pharmacokinetic properties compared to 1, Clotrimazole. Several triarylamides such as 10 and 21 were potent inhibitors of the Gardos channel (IC50 of 10 nM) and active in a mouse model of SCD. Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD.
GARDOS CHANNEL ANTAGONISTS
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, (2008/06/13)
Novel inhibitors of potassium flux are disclosed. The inhibitors show surprising resistance to degradation in biological media and enhanced in vivo half-lives relative to non-fluorine substituted homologues. Methods for the use of these compounds include
