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CAS No.: | 119006-77-8 |
---|---|
Name: | 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C22H16F2N2 |
Molecular Weight: | 346.379 |
Synonyms: | 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole;UR 4056; |
Density: | 1.15 g/cm3 |
Melting Point: | 161-166 °C |
Boiling Point: | 457.1 °C at 760 mmHg |
Flash Point: | 230.3 °C |
PSA: | 17.82000 |
LogP: | 5.00150 |
1H-imidazole
(2-Fluorophenyl)(4-fluorophenyll)phenylchloromethane
flutrimazole
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 3h; Heating; Yield given; |
o-fluorobenzophenone
flutrimazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h 2: thionyl chloride / 4 h / Heating 3: triethylamine / acetonitrile / 3 h / Heating View Scheme |
(2-fluorophenyl)-(4-fluorophenyl)phenylmethanol
flutrimazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Heating 2: triethylamine / acetonitrile / 3 h / Heating View Scheme |
1-Bromo-4-fluorobenzene
flutrimazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 30 min, 2.) reflux, 2.5 h 2: thionyl chloride / 4 h / Heating 3: triethylamine / acetonitrile / 3 h / Heating View Scheme |
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Molecular Formula: C22H16F2N2
Molecular Weight: 346.373 g/mol.
Index of Refraction: 1.59
Density: 1.15 g/cm3
Flash Point: 230.3 °C
Enthalpy of Vaporization: 68.97 kJ/mol
Boiling Point: 457.1 °C at 760 mmHg
Vapour Pressure: 4.16E-08 mmHg at 25 °C
Melting point: 161-166 °C
Structure of Flutrimazole (CAS NO.119006-77-8):
IUPAC Name: 1-[(2-Fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
Product Category of Flutrimazole (CAS NO.119006-77-8): Flutrimazole
Flutrimazole(CAS NO.119006-77-8) is used for the topical treatment of superficial mycoses of the skin, such as tinea in all its forms: tinea pedis (athlete's foot), tinea cruris, tinea corporis, tinea faciei et barbae and tinea inguinalis, caused by Trichophyton, Microsporum and by Epidermophyton floccosum. It is also indicated for the treatment of pityriasis versicolor caused by Malassezia furfur, also known as Pityrosporum ovale.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
rat | LD50 | intraperitoneal | 1079mg/kg (1079mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
rat | LD50 | oral | 808mg/kg (808mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 841, 1992. |
Flutrimazole (CAS NO.119006-77-8) may cause burning, irritation, pruritus and erythema in the treated zone. It shows a very low acute toxicity. Its topical administration does not cause sensitization and has no potential for inducing phototoxicity or photosensitivity.
Flutrimazole , its cas register number is 119006-77-8. It also can be called 1-[(2-Fluorophenyl)-(4-fluorophenyl)phenylmethyl]-1H-imidazole ; Micetal ; and Flusporan . It is a wide spectrum antifungal drug, and is practically insoluble in water, freely soluble in tetrahydrofuran and soluble in methanol. It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol-14-demethylase.