119022-25-2

Upstream product

• 100-46-9 benzylamine 
• 98-86-2 acetophenone 
• 14428-98-9 (Z)-phenyl-N-(1-phenylethylidene)methanamine 
• 83-13-6 diethyl 2-phenylmalonate 
• 15781-73-4 di(2,4,6-trichlorophenyl)-2-phenylmalonate 

Downstream Products

• 24555-54-2 4-hydroxy-3,6-diphenyl-pyridin-2(1H)-on 

Relevant academic research and scientific papers

Synthesis of 4-Hydroxy-2(1H)-pyridones from Azomethines and Substituted Dialkylmalonates

The reaction of azomethines 4 with substituted dialkyl malonates 5 leads to the formation of 3-substituted 4-hydroxy-2(1H)-pyridones 6 in moderate yields. The azomethines 4 are prepared via arylaminopropionitriles 3 or in the conventional way by acid catalyzed condensation of ketones 1 with anilines 2. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 8-10.

Aktive Malonester als Synthons fuer Heterocyclen: Eine Methode zur Hertstellung von 4-Hydroxy-2(1H)-pyridonen

4-Hydroxy-2-(1H)-pyridones 3 can be obtained in excellent yields from azomethines 1 with trichlorophenylmalonates 2.The variation of the substituents in position 1,3,5 or 6, respectively is possible over a wide range.In this manner the 5,6-fused-pyridones