1190769-24-4Relevant academic research and scientific papers
Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents
Bianchi, Aldo,Ugazzi, Marcello,Ferrante, Luca,Lecis, Daniele,Scavullo, Cinzia,Mastrangelo, Eloise,Seneci, Pierfausto
, p. 2204 - 2208 (2012/04/18)
A set of phenyl-substituted Smac mimetics/IAP inhibitor analogues of lead compound 2a was synthesized, aiming to retain its strong cell-free potency while increasing its bioavailability. Seventeen compounds 2b-r were prepared and characterized in vitro, u
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
Seneci, Pierfausto,Bianchi, Aldo,Battaglia, Cristina,Belvisi, Laura,Bolognesi, Martino,Caprini, Andrea,Cossu, Federica,Franco, Elena de,Matteo, Marilenia de,Delia, Domenico,Drago, Carmelo,Khaled, Amira,Lecis, Daniele,Manzoni, Leonardo,Marizzoni, Moira,Mastrangelo, Eloise,Milani, Mario,Motto, Ilaria,Moroni, Elisabetta,Potenza, Donatella,Rizzo, Vincenzo,Servida, Federica,Turlizzi, Elisa,Varrone, Maurizio,Vasile, Francesca,Scolastico, Carlo
supporting information; experimental part, p. 5834 - 5856 (2009/12/06)
Novel proapoptotic Smac mimics/IAPs inhibitors have been designed, synthesized and characterized. Computational models and structural studies (crystallography, NMR) have elucidated the SAR of this class of inhibitors, and have permitted further optimizati
