1366595-49-4Relevant academic research and scientific papers
4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents
Manzoni, Leonardo,Samela, Alessandro,Barbini, Stefano,Cairati, Silvia,Penconi, Marta,Arosio, Daniela,Lecis, Daniele,Seneci, Pierfausto
, p. 2336 - 2344 (2017)
Putative dual action compounds (DACs 3a–d) based on azabicyclo[5.3.0]decane (ABD) Smac mimetic scaffolds linked to Zn2+-chelating 2,2′-dipicolylamine (DPA) through their 4 position are reported and characterized. Their synthesis, their target a
SPION-Smac mimetic nano-conjugates: Putative pro-apoptotic agents in oncology
Seneci, Pierfausto,Rizzi, Mattia,Ballabio, Luigi,Lecis, Daniele,Conti, Annalisa,Carrara, Claudio,Licandro, Emanuela
supporting information, p. 2374 - 2378 (2014/05/20)
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated
Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents
Bianchi, Aldo,Ugazzi, Marcello,Ferrante, Luca,Lecis, Daniele,Scavullo, Cinzia,Mastrangelo, Eloise,Seneci, Pierfausto
supporting information; experimental part, p. 2204 - 2208 (2012/04/18)
A set of phenyl-substituted Smac mimetics/IAP inhibitor analogues of lead compound 2a was synthesized, aiming to retain its strong cell-free potency while increasing its bioavailability. Seventeen compounds 2b-r were prepared and characterized in vitro, u
